drugset / Trial / NCT00358384

Chronic Plaque Psoriasis Study With Topical Formulation Of GW786034

NCT00358384

Phase 1 Completed 10 enrolled GlaxoSmithKline
RandomizedParallel-groupTreatment

Summary

This study is an exploratory study to evaluate the effectiveness, safety and tolerability of three concentrations of GW786034 ointment following treatment to small areas of stable psoriatic plaques. Dosing will proceed using a microplaque approach, where small volumes of ointment will be applied under full occlusion to representative psoriatic plaques. The effectiveness of topical GW786034 treatments and controls will be explored using visual intensity assessments in addition to dermal imaging and histological surrogates of disease activity.

Timeline

Start
2005-09-26
Primary completion
2006-02-24
Completion
2006-02-24

Drugs

EvaluationDrugModalityDoseRoute
Comparator Calcipotriol Small molecule 0.005 % Topical
Subject Pazopanib Small molecule 0.1 % Topical
Subject Pazopanib Small molecule 0.5 % Topical
Subject Pazopanib Small molecule 1 % Topical
Comparator betamethasone valerate Small molecule 0.1 % Topical

Indications