Drugs / Calcipotriol
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Calcipotriol

Small molecule targets TSLP

Developed for
psoriasis · actinic keratosis · skin squamous cell carcinoma · atopic eczema · generalized vitiligo · acne · alopecia areata · breast cancer
+15 more · central centrifugal cicatricial alopecia · common wart · connective tissue disorder · hand dermatosis · localized scleroderma · polymorphic light eruption · radiodermatitis · skin squamous cell carcinoma in situ · squamous cell carcinoma · superficial multifocal basal cell carcinoma · allergic contact dermatitis · androgenetic alopecia · oral mucosa leukoplakia · scleroderma · vitiligo
Investigated by
LEO Pharma · MC2 Therapeutics · GlaxoSmithKline · Massachusetts General Hospital · Mayne Pharma International Pty Ltd · Psoriasis Treatment Center of Central New Jersey
+46 more · Stiefel, a GSK Company · Washington University School of Medicine · Bioskin GmbH · Derm Research, PLLC · Lipidor AB · National Cancer Institute (NCI) · Pfizer · Amgen · Assiut University · Bispebjerg Hospital · Boston University · CMIC Co, Ltd. Japan · Cadila Pharnmaceuticals · Carilion Clinic · Centre Hospitalier Universitaire de Nice · Circassia Limited · Dong-A University · Eisai Inc. · Eli Lilly and Company · Glenmark Pharmaceuticals Ltd. India · Guangdong Provincial Hospital of Traditional Chinese Medicine · Hayat Abad Medical Complex, Peshawar · Hoffmann-La Roche · Icahn School of Medicine at Mount Sinai · Incyte Corporation · Jordan University of Science and Technology · LEO Innovation Lab · Lipidor AB, Svärdvägen 13 SE-182 33 Danderyd, Sweden · M.D. Anderson Cancer Center · Maastricht University Medical Center · Mazandaran University of Medical Sciences · Medical University of Graz · Melissa Pugliano-Mauro · National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) · Northwestern University · Rabin Medical Center · TetraLogic Pharmaceuticals · Tolmar Inc. · Tulane University · University of Alabama at Birmingham · University of Arizona · University of California, Los Angeles · University of California, San Francisco · University of Pittsburgh · Wake Forest University Health Sciences · Xijing Hospital

Regulatory milestones approvals, filings & regulatory actions · 7 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansions (3) US (FDA) SORILUX 2012-09-27 – 2019-11-05 fda.gov
Label expansions (3) US (FDA) DOVONEX 1996-08-15 – 1999-07-07 fda.gov
Approved US (FDA) DOVONEX 1993-12-29 fda.gov

Trials 94 · started per year

today
US approved 1993
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5
2
2
5
3
9
3
5
9
3
2
2
4
13
7
4
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1
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199319941995199619971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 05 trials
Phase 0 NCT05416320 Aug → Nov 2023 central centrifugal cicatricial alopecia Wake Forest University Health Sciences Withdrawn No outcome recorded
Phase 0 NCT04839731 Apr 2021 → Dec 2023 skin squamous cell carcinoma Carilion Clinic Unknown No outcome recorded
Phase 0 NCT03996252 Jul 2019 → Jan 2020 actinic keratosis Tulane University Terminated No outcome recorded
Phase 0 NCT02411643 Mar 2015 → Apr 2016 localized scleroderma Northwestern University Terminated No outcome recorded
Phase 0 NCT02019355 Oct 2013 → Mar 2015 actinic keratosis Washington University School of Medicine Completed No outcome recorded
Phase 126 trials
Phase 1 NCT03898583 Apr → Oct 2019 psoriasis LEO Pharma Completed No outcome recorded
Phase 1 NCT03892564 Feb → Mar 2019 phototoxic dermatitis MC2 Therapeutics Completed No outcome recorded
Phase 1 NCT03899064 Feb → Apr 2019 photoallergic dermatitis MC2 Therapeutics Completed No outcome recorded
Phase 1 NCT03596073 Nov 2018 → Aug 2020 breast cancer Massachusetts General Hospital Terminated No outcome recorded
Phase 1 NCT03758365 Nov 2018 vascular disorder MC2 Therapeutics Completed No outcome recorded
Phase 1 NCT03370406 Aug 2018 → Sep 2027 expected squamous cell carcinoma Melissa Pugliano-Mauro Recruiting No outcome recorded
Phase 1 NCT03469336 Apr 2018 → Mar 2019 psoriasis Pfizer Completed No outcome recorded
Phase 1 NCT03476746 Mar → Jul 2018 LEO Pharma Completed No outcome recorded
Phase 1 NCT03442244 Jan → Feb 2018 psoriasis LEO Pharma Completed No outcome recorded
Phase 1 NCT03234673 Aug 2017 → Aug 2018 generalized vitiligo Assiut University Unknown No outcome recorded
Phase 1/23 trials
Phase 1/2 NCT03392311 Jul → Oct 2019 poisoning, psoriasis Guangdong Provincial Hospital of Traditional Chinese Medicine Completed No outcome recorded
Phase 1/2 NCT05488990 Mar → Jun 2013 psoriasis Lipidor AB Completed No outcome recorded
Phase 1/2 NCT01768013 Jul → Oct 2012 psoriasis LEO Pharma Completed No outcome recorded
Phase 221 trials
Phase 2 NCT04329221 Jan 2026 → Jan 2029 actinic keratosis, skin squamous cell carcinoma Massachusetts General Hospital Withdrawn No outcome recorded
Phase 2 NCT04642287 Jan 2026 → Jan 2029 actinic keratosis, disease related to solid organ transplantation, skin squamous cell carcinoma Massachusetts General Hospital Withdrawn No outcome recorded
Phase 2 NCT05699603 Jul 2024 → Feb 2027 expected actinic keratosis University of Arizona Active not recruiting No outcome recorded
Phase 2 NCT04580537 Oct 2020 → Jun 2021 psoriasis Bispebjerg Hospital Completed No outcome recorded
Phase 2 NCT03819218 Dec 2018 → Dec 2020 psoriasis MC2 Therapeutics Terminated No outcome recorded
Phase 2 NCT03584360 Sep 2018 psoriasis Centre Hospitalier Universitaire de Nice Completed No outcome recorded
Phase 2 NCT03462927 Feb → Aug 2018 psoriasis MC2 Therapeutics Completed No outcome recorded
Phase 2 NCT02038569 Jan 2014 → Feb 2018 psoriasis LEO Pharma Completed No outcome recorded
Phase 2 NCT01600222 May 2012 → May 2013 psoriasis LEO Pharma Completed No outcome recorded
Phase 2 NCT01229098 Oct 2010 → Sep 2011 psoriasis LEO Pharma Completed No outcome recorded
Phase 2/32 trials
Phase 2/3 NCT05381597 Oct 2022 → Jun 2027 expected skin squamous cell carcinoma in situ, superficial multifocal basal cell carcinoma Boston University Recruiting No outcome recorded
Phase 2/3 NCT01694433 Feb 2013 → Jan 2014 acne University of California, Los Angeles Completed No outcome recorded
Phase 319 trials
Phase 3 NCT06851507 Oct 2025 → Aug 2027 expected actinic keratosis M.D. Anderson Cancer Center Recruiting No outcome recorded
Phase 3 NCT05249972 Jan → Aug 2022 psoriasis Lipidor AB Unknown No outcome recorded
Phase 3 NCT03806790 Jan → Jun 2019 psoriasis LEO Pharma Completed No outcome recorded
Phase 3 NCT03802344 Dec 2018 → Oct 2019 psoriasis MC2 Therapeutics Completed No outcome recorded
Phase 3 NCT03731091 Oct 2018 → Mar 2020 psoriasis Glenmark Pharmaceuticals Ltd. India Completed No outcome recorded
Phase 3 NCT05174598 Oct 2018 → Nov 2019 psoriasis Cadila Pharnmaceuticals Completed No outcome recorded
Phase 3 NCT02668692 Feb → Jun 2016 psoriasis LEO Pharma Completed No outcome recorded
Phase 3 NCT01866163 Jun → Oct 2013 psoriasis LEO Pharma Completed No outcome recorded
Phase 3 NCT01313221 Apr 2011 → Dec 2012 psoriasis Amgen Completed No outcome recorded
Phase 3 NCT01188928 Sep 2010 → Mar 2011 psoriasis LEO Pharma Completed No outcome recorded
Phase 414 trials
Phase 4 NCT07352566 Aug 2026 → Jun 2030 expected atopic eczema, psoriasis University of California, San Francisco Not yet recruiting No outcome recorded
Phase 4 NCT07453238 Apr → Oct 2026 expected alopecia areata Hayat Abad Medical Complex, Peshawar Not yet recruiting No outcome recorded
Phase 4 NCT06499415 Sep 2024 → Mar 2029 expected actinic keratosis Maastricht University Medical Center Recruiting No outcome recorded
Phase 4 NCT04227288 Nov 2021 → Oct 2023 psoriasis University of Alabama at Birmingham Completed No outcome recorded
Phase 4 NCT04555707 Jun 2020 → Jun 2021 psoriasis Derm Research, PLLC Unknown No outcome recorded
Phase 4 NCT04372277 Apr 2020 → Mar 2021 overdue psoriasis Psoriasis Treatment Center of Central New Jersey Recruiting No outcome recorded
Phase 4 NCT03827876 Jan → Sep 2019 overdue psoriasis Psoriasis Treatment Center of Central New Jersey Recruiting No outcome recorded
Phase 4 NCT03506477 May 2018 → Sep 2019 psoriasis Icahn School of Medicine at Mount Sinai Completed No outcome recorded
Phase 4 NCT03848871 Dec 2017 → Nov 2018 psoriasis Derm Research, PLLC Completed No outcome recorded
Phase 4 NCT03080545 May → Oct 2017 psoriasis Psoriasis Treatment Center of Central New Jersey Completed No outcome recorded
Phase not applicable4 trials
NCT06737406 May 2025 → Jul 2026 overdue common wart Mazandaran University of Medical Sciences Recruiting No outcome recorded
NCT04440371 Jun 2020 → Jul 2023 generalized vitiligo Jordan University of Science and Technology Unknown No outcome recorded
NCT02191007 Nov 2013 → May 2014 psoriasis Xijing Hospital Completed No outcome recorded
NCT00871052 Mar → May 2009 polymorphic light eruption Medical University of Graz Completed No outcome recorded
Also used as a comparator or background therapy in 54 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT06880042 Comparator May → Jun 2025 overdue vitiligo Dr ayesha wahid Enrolling by invitation No outcome recorded
Phase 17 trials
Phase 1 NCT04221906 Comparator Jan → Mar 2020 psoriasis Boston Pharmaceuticals Completed No outcome recorded
Phase 1 NCT03880357 Comparator Oct 2018 → Mar 2019 psoriasis Sun Pharmaceutical Industries, Inc. Completed No outcome recorded
Phase 1 NCT02999776 Comparator Nov 2016 → Dec 2017 psoriasis Pantec Biosolutions AG Unknown No outcome recorded
Phase 1 NCT02940002 Comparator Oct 2016 → Jan 2017 psoriasis Bayer Completed No outcome recorded
Phase 1 NCT02680717 Comparator Mar 2016 → May 2017 scleroderma Medical College of Wisconsin Withdrawn No outcome recorded
Phase 1/25 trials
Phase 1/2 NCT06333600 Comparator May 2023 → Apr 2024 androgenetic alopecia, skin disorder Sohag University Unknown No outcome recorded
Phase 1/2 NCT02432027 Comparator Jun → Aug 2015 psoriasis Prism Pharma Co., Ltd. Completed No outcome recorded
Phase 1/2 NCT03069144 Comparator Jan → Apr 2012 psoriasis Haus Bioceuticals Completed No outcome recorded
Phase 1/2 NCT00987870 Comparator Sep 2009 → Feb 2010 arthritic joint disease, psoriasis Novartis Pharmaceuticals Completed No outcome recorded
Phase 1/2 NCT00578370 Comparator Nov 2007 → Apr 2008 psoriasis ISDIN Completed No outcome recorded
Phase 212 trials
Phase 2 NCT07410793 Comparator Feb 2026 → Feb 2027 expected psoriasis Mae Fah Luang University Recruiting No outcome recorded
Phase 2 NCT03448081 Comparator Feb → Nov 2018 psoriasis Sienna Biopharmaceuticals Completed No outcome recorded
Phase 2 NCT03848806 Comparator Feb → Jul 2016 psoriasis Haus Bioceuticals Completed No outcome recorded
Phase 2 NCT02518048 Comparator Aug 2015 → Jan 2016 connective tissue disorder LEO Pharma Completed No outcome recorded
Phase 2 NCT02416258 Comparator Apr → Jun 2015 connective tissue disorder LEO Pharma Completed No outcome recorded
Phase 2/34 trials
Phase 2/3 NCT07658508 Comparator Jul 2025 → Aug 2026 overdue oral mucosa leukoplakia Alexandria University Active not recruiting No outcome recorded
Phase 2/3 NCT04071106 Comparator Sep → Dec 2019 psoriasis Zagazig University Unknown No outcome recorded
Phase 2/3 NCT01763424 Comparator Jul 2011 → Dec 2012 psoriasis Isfahan University of Medical Sciences Completed No outcome recorded
Phase 2/3 NCT01445886 Comparator Jan 2011 → Jun 2012 psoriasis Yin-ku Lin Completed No outcome recorded
Phase 310 trials
Phase 3 NCT07453472 Comparator Apr 2026 → Oct 2028 expected oral mucosa leukoplakia All India Institute of Medical Sciences Not yet recruiting No outcome recorded
Phase 3 NCT03331523 Comparator Oct 2017 → Oct 2018 psoriasis Glenmark Pharmaceuticals Ltd. India Completed No outcome recorded
Phase 3 NCT02899962 Comparator Feb 2017 → Jun 2019 psoriasis LEO Pharma Completed No outcome recorded
Phase 3 NCT02644954 Comparator Jan → Jun 2016 psoriasis Post Graduate Institute of Medical Education and Research, Chandigarh Unknown No outcome recorded
Phase 3 NCT02310646 Comparator Jan → Jul 2015 psoriasis LEO Pharma Completed No outcome recorded
Phase 48 trials
Phase 4 NCT04571151 Comparator Jan → Nov 2021 psoriasis Skin Sciences, PLLC Unknown No outcome recorded
Phase 4 NCT03866447 Comparator Oct 2019 → Nov 2020 acne Assiut University Unknown No outcome recorded
Phase 4 NCT02858713 Background Jan → Apr 2017 Odense University Hospital Completed No outcome recorded
Phase 4 NCT02533973 Comparator Sep 2015 → Mar 2018 psoriasis LEO Pharma Completed No outcome recorded
Phase 4 NCT02733874 Comparator Apr 2015 → Apr 2016 psoriasis First Hospital of China Medical University Completed No outcome recorded
Phase not applicable7 trials
NCT06685588 Comparator Jan 2025 → Jan 2026 overdue actinic keratosis St Vincent's University Hospital, Ireland Not yet recruiting No outcome recorded
NCT05954104 Comparator Jul → Oct 2023 alopecia areata Egymedicalpedia Completed No outcome recorded
NCT06011083 Comparator Aug 2022 → Feb 2023 psoriasis Assiut University Completed No outcome recorded
NCT04275024 Background Apr → Jun 2020 poisoning, psoriasis Guangdong Provincial Hospital of Traditional Chinese Medicine Completed No outcome recorded
NCT03847441 Comparator Oct 2017 → Dec 2018 alopecia areata Aswan University Hospital Completed No outcome recorded

Evidence & citations 16 cited values

Every value below carries the sentence it was read from. 152 sources stand behind the page.

FieldValueCited text
Known as calcipotriol “A Phase 2 Maximal Use Systemic Exposure Study Evaluating the Safety and Efficacy of Calcipotriol 50 mcg/g Plus Betamethasone 0.5 mg/g (as Dipropionate) Gel Applied Once Daily...” NCT01229098
93

“A phase 2 trial evaluating the safety and efficacy of once daily use of LEO 80185 gel containing calcipotriol 50 mcg/g plus betamethasone 0.5mg/g (as dipropionate) in...” NCT02038569

“treatment with Xamiol® gel (calcipotriol 50 mcg/g plus betamethasone 0.5 mg/g (as dipropionate)) once daily (as required) with Daivonex® scalp solution (calcipotriol 50 mcg/g)...” NCT02533973

“fixed-dose combination calcipotriol 50 μg/g + betamethasone dipropionate 0.5 mg/g (Cal/BD) cutaneous foam has been approved (Enstilar®, LEO Pharma) in the USA and EU for the...” PMID 32785881 Aug 2020

“A foam formulation of calcipotriol and betamethasone dipropionate (Cal/BD foam), consisting of calcipotriol 50 μg/g and betamethasone dipropionate 0.5 mg/g, is approved for the...” PMID 32965655 Sep 2020

“Participants received each of the following six treatments once daily for 18 days: three topical doses (2.3%, 0.8%, 0.23%) of PF-06763809, a vehicle and two active comparators...” PMID 32767679 Sep 2020

“Daily self-administration of 1 to 5g Daivobet (Calcipotriol 50ug/g +Betamethasone, 0,5mg/g Gel) ointment, which is applied topically once per day for 8 weeks on one...” NCT02999776

“Effect of Calcipotriol Plus Betamethasone Dipropionate Topical Suspension on the HPA Axis and Calcium Metabolism in Adolescent Subjects (Aged 12 to 17 Years) With Scalp Psoriasis” NCT01083758

“LEO 90100 aerosol foam, containing calcipotriol (as hydrate) 50 mcg/g and betamethasone 0.5 mg/g (as dipropionate), 60 g per can, applied once daily up to 12 weeks” NCT02132936

“Ablative fractional laser (AFL) pre-treatment + daily use of Enstilar (cutaneous foam: 0.5 mg/g betamethasone dipropionate, 0.05mg/g calcipotriol)” NCT04580537

“The pharmacokinetics of LEO 90105 (calcipotriol hydrate plus betamethasone dipropionate) in Japanese subjects with extensive psoriasis vulgaris.” NCT01768013

“LEO 90100 foam (containing calcipotriol hydrate 52.2 µg/g \[equivalent to 50.0 µg/g calcipotriol\] plus betamethasone dipropionate 0.643 mg/g).” NCT03476746

Calcipotriol 50 mcg/g (as hydrate) and betamethasone 0.5 mg/g (as dipropionate) Aerosol Foam 60 g per can, applied once daily for one week” NCT02310646

“LEO 90100 foam contains Calcipotriol hydrate 52.2 μg/g (equivalent to 50.0 μg/g calcipotriol) plus Betamethasone dipropionate 0.643 mg/g” NCT03442244

“Safety and Efficacy of Calcipotriol Plus Betamethasone Dipropionate Gel in Adolescent Subjects (Aged 12 to 17) With Scalp Psoriasis” NCT01120223

“Skin Irritation Test of LEO 80185 Gel (Calcipotriol Hydrate Plus Betamethasone Dipropionate) in Healthy Japanese Subjects” NCT02379793

Calcipotriol (as monohydrate) 50 mcg/g and betamethasone (as dipropionate) 0.5 mg/g (LEO 90100 Aerosol foam)” NCT02518048

“This group will be treated by topical Vitamin D analogue (Calcipotriol) versus placebo (panthenol).” NCT03866447

“Daivonex solution (50 ug/ml Calcipotriol) Daily Dosage of calcipotriol: approximately 0.01 mg” NCT02193815

“LEO 90100 calcipotriol 50 mcg/g and betamethasone 0.5 mg/g (as dipropionate) aerosol foam” NCT02973776

Calcipotriol 50 mcg/g Plus Betamethasone 0.5 mg/g (as Dipropionate) Topical Suspension” NCT01188928

Calcipotriol 50 mcg/g (as hydrate) and betamethasone 0.5 mg/g (as dipropionate)” NCT01600222

“Topical application of vitamin D3 analogue (Calcipotriol ointment)” NCT06333600

“* calcipotriol plus betamethsone dipropionate 0.05%” NCT01313221

“equivalent to 50.0 µg/g calcipotriolNCT02668692

CalcipotriolNCT03898583

NCT00216840

NCT02644954

NCT05174598

NCT05249972

NCT00248456

NCT00445250

NCT03069144

NCT00875277

NCT00691002

NCT06737406

NCT00764751

NCT01413477

NCT01536938

NCT01368887

NCT07453238

NCT07453472

NCT01043224

NCT01195831

NCT05954104

NCT00670241

NCT00796211

NCT03848806

NCT06685588

NCT04275024

NCT01763424

NCT00704262

NCT04440371

NCT01536886

NCT01422434

NCT00358384

NCT00640822

NCT03847441

NCT00392067

NCT04071106

NCT01466478

NCT00263718

NCT01646567

NCT00243464

NCT01837576

NCT04221906

NCT05416320

NCT01297166

NCT03234673

NCT04329221

NCT00216827

NCT06499415

NCT00871052

NCT03392311

NCT00578370

NCT02416258

NCT00216879

NCT00216892

NCT07410793

NCT00404196

NCT06011083

NCT01105286

NCT01105234

NCT07658508

NCT02191007

NCT05488990

NCT00705900

NCT04642287

NCT00987870

NCT02733874

NCT02019355

NCT01445886

NCT06880042

NCT02976727

Known as AKVANO “Calcipotriol/AKVANO, 50 μg/g cutaneous solution” NCT05174598
Known as CAL “Fixed combination calcipotriol as hydrate (Cal) 50 µg/g plus betamethasone as dipropionate (BD) 0.5 mg/g aerosol foam is an alcohol-free treatment for psoriasis.” PMID 27995521 Apr 2017
3

Calcipotriol (CAL) enhances thymic stromal lymphopoietin (TSLP), an epithelium-derived cytokine, which promotes antitumor immunity.” NCT06499415

“combination of calcipotriene (CAL) and betamethasone dipropionate (BDP)” PMID 37490268 Jul 2023

calcipotriene \[CAL\]/betamethasone dipropionate \[BDP\] ointment” NCT03462927

Known as calcipotriene “The combination topical suspension of calcipotriene 0.005% and betamethasone dipropionate 0.064% is a first-line treatment for moderate to severe psoriasis vulgaris and is FDA...” NCT01761019
49

“Taclonex® (calcipotriene 0.005% and betamethasone dipropionate 0.064%) Ointment and Taclonex Scalp® (calcipotriene 0.005% and betamethasone dipropionate 0.064%) Topical...” NCT01707043

“This study will evaluate the efficacy of Enstilar® foam, a combination of calcipotriene and betamethasone dipropionate 0.005%/0.064%, in the treatment of psoriasis vulgaris in...” NCT03506477

“Open Label Study, Evaluating Taltz in Combination With Enstilar (Calcipotriene and Betamethasone Dipropionate) Foam in Psoriasis Patients” NCT04372277

“Enstilar® (Calcipotriene and Betamethasone Dipropionate) Foam, 0.005%/0.064% QD in Psoriasis Patients Being Treated With Biologic Agents” NCT03080545

“Applications with MC2-01 Cream (calcipotriene/betamethasone dipropionate, w/w 0.005%/0.064%), followed by irradiation” NCT03899064

“MC2-01 Cream (calcipotriene/betamethasone dipropionate, w/w 0.005%/0.064%) cream, followed by irradiation” NCT03892564

“Single application of MC2-01 (calcipotriene/betamethasone dipropionate, w/w 0.005%/0.064%) cream” NCT03758365

“Enstilar® (Calcipotriene and Betamethasone Dipropionate) Foam, 0.005%/0.064%” NCT03827876

“MC2-01 cream (Calcipotriene/betamethasone dipropionate, w/w 0.005%/ 0.064%)” NCT03819218

“MC2-01 (calcipotriene/betamethasone dipropionate, w/w 0,005%/0,064%) cream” NCT03802344

“MC2-01 (calcipotriene/betamethasone dipropionate, w/w 0.005%/0.064%)” NCT03462927

calcipotriene hydrate/betamethasone dipropionate (Enstilar) foam” NCT03848871

“Enstilar Foam (Calcipotriene and Betamethasone Dipropionate)” NCT04227288

“commercially available calcipotriene 0.005% cream (Dovonex)” PMID 20513160 2010

“Calcipotriol (Calcipotriene) is a form of vitamin D.” NCT04329221

“U0267 is a vitamin D3 analog (calcipotriene) foam.” NCT00689481

“U0267 is a vitamin D3 analog (calcipotriene) foam.” NCT00688519

“SORILUX Foam contains calcipotriene 50 mcg/g.” NCT04571151

NCT05381597

NCT00820950

NCT05699603

NCT03399526

NCT00817219

NCT02680717

NCT00625326

NCT01139580

NCT07352566

NCT04839731

NCT01745133

NCT03370406

NCT03996252

NCT02858713

NCT01268527

NCT01188928

NCT04555707

NCT03596073

NCT02940002

NCT00437255

NCT03448081

NCT01563068

NCT03584360

NCT01694433

NCT01582932

NCT03331523

NCT02411643

NCT03731091

NCT03469336

NCT06851507

NCT00279162

Known as Calcipotriene and betamethasone suspension ClinicalTrials.gov intervention name — accepted as the source's own label NCT03122353
Known as Calcipotriene Hydrate “Taclonex® (Calcipotriene Hydrate and Betamethasone Dipropionate) Topical suspension 0.005%/0.064% (LEO PHARMA)” NCT03880357
Known as calcipotriol hydrate calcipotriol hydrate 52.2 µg/g” NCT03806790
1

NCT00437619

Known as Daivonex “Calcipotriol solution (Daivonex® scalp solution, calcipotriol 50 ug/ml) was purchased from LEO Pharmaceutical Products, Ltd. (Ballerupt, Denmark) and also distributed into 5-ml...” NCT01445886
9

“Calcipotriol ointment 50 mcg/g (Daivonex, Leo Pharma, Denmark) was applied twice for daily on treatment area for 15 consecutive days.” NCT02976727

Daivonex solution (50 ug/ml Calcipotriol) Daily Dosage of calcipotriol: approximately 0.01 mg” NCT02193815

“Daily application of Daivonex cream (calcipotriol 0.005%)” NCT04221906

“with Daivonex® scalp solution (calcipotriol 50 mcg/g)” NCT02533973

“calcipotriol hydrate [Daivonex]” NCT00437619

NCT02432027

NCT01466478

NCT01743118

NCT01580488

Known as Dovonex “The topical treatment in the study was calcipotriol ointment(Dovonex;LEO Laboratories Ltd, Ireland) twice daily for 12 weeks.” NCT03392311
7

“two different creams (5-fluorouracil, known as Efudix, and calcipotriol, known as Dovonex)” NCT06685588

“commercially available calcipotriene 0.005% cream (Dovonex)” PMID 20513160 2010

Dovonex® calcipotriene 0.005%” NCT00820950

Dovonex® = calcipotriol” NCT01422434

DovonexNCT04275024

NCT01301157

NCT00764751

Known as Dovonex (calcipotriol ointment, DIN 01976133 Leo Pharma), Dovonex (calcipotriol ointment, DIN 01976133 Leo Pharma),NCT01413477
Known as Sorilux “The study drugs that will be used in this study are Lexette® (0.05% Halobetasol propionate foam) and Sorilux® (calcipotriene foam).” NCT04571151
Known as U0267 U0267 is a vitamin D3 analog (calcipotriene) foam.” NCT00689481
1

U0267 is a vitamin D3 analog (calcipotriene) foam.” NCT00688519

Action Inhibit “It inhibits keratinocyte proliferation (cell growth)” NCT03370406
Modality Small molecule “vitamin D analogues such as calcipotriol are used to treat psoriasis.” NCT01413477
Route Topical “once daily topical treatment for up to 8 weeks” NCT00216840
Target TSLP “synergistic impact of TSLP induction by calcipotriol in combination with the cytotoxic effects of 5-FU” NCT04642287