Topical Calcipotriol Versus Photodynamic Therapy in the Treatment of Oral Leukoplakia

Summary

The goal of this clinical trial is to learn if calcipotriol and photodynamic therapy are equally effective in treatment of leukoplakia or not. The main questions it aims to answer are: do lesions decrease or disappear when treated by calcipotriol or PDT? does the drug affect the salivary biomarkers Participants will: Take calcipotriol daily for 4 weeks or perform 4 PDT sessions over 4 weeks measure changes in salivary biomarkers be followed up for 3 months

Timeline

Start

2025-07-16

Primary completion

2026-08-10

Completion

2026-09-10

Publications

• Background Ghalwash D, Mahmoud E, Shaker O. Evaluation Of The Therapeutic Effect Of Topical Calcipotriol Versus Topical Tretinoin In Treatment Of Oral Leukoplakia And Their Effect On Clinical Improvement And Salivary Level Of Mmp-9, Il-6 And Tgf- Β: A Randomized Clinical Trial. Dentistry. 2017 Jan 1

Drugs

Indications