drugset / Trial / NCT00362934
Comparison of the Combination of Fenofibrate and Simvastatin Versus Atorvastatin
RandomizedParallel-groupQuadruple-blindTreatment
Summary
Mixed or combined hyperlipidemia is a common metabolic disorder characterized by both hypercholesterolemia and hypertriglyceridemia. Statins and fibrates have complementary mechanisms and can be coadministered to patients with mixed hyperlipidemia. The overall objective of the study is to compare the efficacy and safety of combining fenofibrate and simvastatin versus atorvastatin monotherapy in patients with mixed hyperlipidemia at risk of cardiovascular diseases.
Timeline
- Start
- 2006-10
- Primary completion
- 2008-08
- Completion
- 2008-08
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Atorvastatin | Small molecule | 10 mg | — |
| Comparator | Atorvastatin | Small molecule | 20 mg | — |
| Subject | Fenofibrate | Small molecule | 145 mg | — |
| Subject | Simvastatin | Small molecule | 20 mg | — |
| Subject | Simvastatin | Small molecule | 40 mg | — |