Trial of Cervical Ripening and Labor Induction Using Misoprostol With or Without Intravaginal Isosorbide Mononitrate

Completed 156 enrolled Stanford University

RandomizedSingle-groupOpen-labelTreatment

Summary

The purpose of this study is to determine the efficacy and safety of the addition of intravaginal isosorbide mononitrate to an established protocol of oral misoprostol for cervical ripening and labor induction.

Timeline

Start: 2006-09
Primary completion: 2007-12
Completion: 2010-01

Publications

Collingham JP, Fuh KC, Caughey AB, Pullen KM, Lyell DJ, El-Sayed YY. Oral misoprostol and vaginal isosorbide mononitrate for labor induction: a randomized controlled trial. Obstet Gynecol. 2010 Jul;116(1):121-126. doi: 10.1097/AOG.0b013e3181e408f2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Isosorbide Mononitrate	Other / unclassified	40 mg	Other
Comparator	Misoprostol	Other / unclassified	100 ug	Oral

Trial of Cervical Ripening and Labor Induction Using Misoprostol With or Without Intravaginal Isosorbide Mononitrate

Summary

Timeline

Publications

Drugs

Indications