Misoprostol

also known as Cytotec · Misotac · Angusta · Vagiprost · Cytotec (brand name) · Misodel · Misoprostol (Cytotec) · Misoprostol is also known as Cytotec · +7 more

Other / unclassified

Developed for: cervix disorder · pregnancy disorder · pregnancy disorder with abortive outcome · leiomyoma · menstrual disorder · uterine disorder · endometrial disorder · habitual spontaneous abortion
+34 more
· indomethacin embryofetopathy · pregnancy loss, recurrent, 4 · cervical cancer · Clostridium difficile colitis · constipation disorder · dystocia · endometrial polyp · gas bloat syndrome · hemorrhagic disease · hypertension, pregnancy-induced · morbid obesity · newborn respiratory distress syndrome · obstetric disorder · perinatal disease · persistent tachypnoe of infancy, usual · preeclampsia · preterm premature rupture of the membranes · submucous uterine fibroid · uterine inflammatory disease · active peptic ulcer disease · cervical dystonia · female reproductive system disorder · fetal growth restriction · gastric ulcer · gastroduodenitis · gestational diabetes · metabolic dysfunction-associated steatohepatitis · oligohydramnios · pain agnosia · placenta disorder · placenta praevia · severe pre-eclampsia · ulcer disease · uterine corpus leiomyoma
Investigated by: Gynuity Health Projects · Ain Shams University · Assiut University · Cairo University · Ferring Pharmaceuticals · Aswan University Hospital
+179 more
· Family Care International · University of California, San Francisco · University of Pittsburgh · Aga Khan Health Services · China Medical University Hospital · Department of Medical Services Ministry of Public Health of Thailand · Hormozgan University of Medical Sciences · Ibis Reproductive Health · Jawaharlal Nehru Medical College · The Aga Khan Foundation · University of Liverpool · University of Pennsylvania · Aga Khan University · Assistance Publique - Hôpitaux de Paris · Assistance Publique Hopitaux De Marseille · Assuta Ashdod Hospital · Bill and Melinda Gates Foundation · Boston University · HaEmek Medical Center, Israel · Islamabad Medical and Dental College · Karolinska Institutet · Mahidol University · Mbarara University of Science and Technology · Montefiore Medical Center · National Cancer Institute (NCI) · Northwestern University · Planned Parenthood League of Massachusetts · Society of Family Planning · Stony Brook University · University of Arizona · University of Utah · hany farouk · American University of Beirut Medical Center · Antonios Likourezos · Assuta Medical Center · AstraZeneca · Aultman Health Foundation · Bangkok Metropolitan Administration Medical College and Vajira Hospital · Beni-Suef University · Bezmialem Vakif University · Bharatpur Eye Hospital · Brigham and Women's Hospital · CHA University · CREHPA · Cameroon Baptist Convention Health · Canadian Anesthesiologists' Society · Center for Research on Environment, Health and Population Activities · Centre de Formation et de la Recherche, Tunisia · Centro Rosarino de Estudios Perinatales · Charitable Foundation Women Health & Family Planning · ChildFund International · Cipla Ltd. · Clinical Hospital Merkur · Columbia University · Consorci Sanitari de Terrassa · Daga Memorial Women's Hospital, Nagpur, India · David Young · Department of Health and Family Welfare, Government of Gujarat · Department of Medical Research, Lower Myanmar · Dr. Sami Ulus Children's Hospital · Effective Care Research Unit · El Galaa Teaching Hospital · Emory University · Faculty of Medicine of Tunis · Fogarty International Center of the National Institute of Health · Global Network for Women's and Children's Health Research · Government Medical College, Nagpur · Guttmacher Institute · HAWLER Maternity Hospital · Hagar Muhammad Abdulfattah Muhammad · Hamna Khaliq · Hawler Medical University · Hayat Abad Medical Complex, Peshawar · Henry Aristoteles Mate-Sánez · all 185 on the full record

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Approved	US (FDA)	CYTOTEC	—	1988-12-27	fda.gov ↗

Trials 220 · started per year

today

US approved 1988

198819891990199119921993199419951996199719981999200020012002200320042005200620072008200920102011201220132014201520162017201820192020202120222023202420252026202720282029

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 05 trials · 1 met primary
Phase 0	NCT06874049	Feb → Aug 2025 overdue	—	Hagar Muhammad Abdulfattah Muhammad	Active not recruiting	No outcome recorded
Phase 0	NCT06199154	Jul 2024 → May 2026 overdue	morbid obesity, pregnancy disorder	University of Maryland, Baltimore	Recruiting	No outcome recorded
Phase 0	NCT04768010	Aug → Sep 2023	constipation disorder, gas bloat syndrome	Montefiore Medical Center	Withdrawn	No outcome recorded Stop: Enrollment
Phase 0	NCT02424201	Jun → Dec 2015	pregnancy disorder	Lagos State University	Unknown	Met primary
Phase 0	NCT02259309	Nov 2014 → Jul 2015	—	Vanderbilt University	Completed	No outcome recorded
Phase 17 trials · 1 met primary
Phase 1	NCT07526064	May → Jul 2026 overdue	pregnancy disorder with abortive outcome	Hamna Khaliq	Not yet recruiting	No outcome recorded
Phase 1	NCT06502158	Oct 2024 → Oct 2026 expected	—	Montefiore Medical Center	Recruiting	No outcome recorded
Phase 1	NCT06364098	Jan 2022 → Feb 2023	—	Cairo University	Completed	Met primary
Phase 1	NCT01863706	May → Dec 2013	—	Hormozgan University of Medical Sciences	Completed	No outcome recorded
Phase 1	NCT01271257	Jan 2011 → Dec 2014	—	China Medical University Hospital	Completed	No outcome recorded
Phase 1	NCT00592215	Mar 2008 → Apr 2010	—	Johns Hopkins University	Withdrawn	No outcome recorded
Phase 1	NCT00906126	Apr 2007 → Sep 2008	dystocia	University of Texas Southwestern Medical Center	Completed	No outcome recorded
Phase 1/21 trial
Phase 1/2	NCT00432588	—	preeclampsia, preterm premature rupture of the membranes	Hormozgan University of Medical Sciences	Unknown	No outcome recorded
Phase 226 trials · 1 missed
Phase 2	NCT06452719	Aug 2024 → Jul 2026 overdue	pregnancy disorder with abortive outcome, pregnancy loss, recurrent, 4	University of Pennsylvania	Recruiting	No outcome recorded
Phase 2	NCT05216952	May 2022 → Jan 2023	pregnancy disorder with abortive outcome	University of North Carolina, Chapel Hill	Completed	No outcome recorded
Phase 2	NCT05207644	Dec 2021 → Apr 2022	pregnancy disorder	Gynuity Health Projects	Completed	No outcome recorded
Phase 2	NCT04724187	Feb → Aug 2021	—	Islamabad Medical and Dental College	Unknown	No outcome recorded
Phase 2	NCT04604366	Nov 2020 → Dec 2021	pregnancy disorder with abortive outcome	Islamabad Medical and Dental College	Completed	No outcome recorded
Phase 2	NCT03972358	Feb 2020 → Dec 2021	menstrual disorder	Gynuity Health Projects	Unknown	No outcome recorded
Phase 2	NCT03927807	Mar → Dec 2019	—	Ain Shams University	Unknown	No outcome recorded
Phase 2	NCT03617172	Nov 2018 → Sep 2021	Clostridium difficile colitis	Vanderbilt University Medical Center	Terminated	No outcome recorded Stop: Enrollment
Phase 2	NCT03939663	Jul 2018 → Jul 2019	—	Ain Shams University	Unknown	No outcome recorded
Phase 2	NCT02685085	Feb → Aug 2016	—	Woman's Health University Hospital, Egypt	Unknown	No outcome recorded
Phase 2	NCT02989324	Jan 2016 → Nov 2017	—	Zagazig University	Completed	No outcome recorded
Phase 2	NCT02409407	Apr 2015 → Apr 2016	infertility disorder	Kasr El Aini Hospital	Unknown	No outcome recorded
Phase 2	NCT02316301	Jan → Dec 2015	—	Cairo University	Completed	Mixed
Phase 2	NCT01866488	Apr 2013 → Oct 2016	—	University of Arizona	Unknown	No outcome recorded
Phase 2	NCT01765881	Sep 2012 → Sep 2015	uterine disorder	University Hospital, Toulouse	Completed	No outcome recorded
Phase 2	NCT01283022	May → Jul 2011	cervix disorder	Ferring Pharmaceuticals	Completed	No outcome recorded
Phase 2	NCT01134926	Jun 2010 → May 2012	uterine disorder	HaEmek Medical Center, Israel	Terminated	No outcome recorded
Phase 2	NCT00925938	Jan → Nov 2010	cervix disorder	Ferring Pharmaceuticals	Completed	No outcome recorded
Phase 2	NCT00828711	Apr → Dec 2009	cervix disorder	Ferring Pharmaceuticals	Completed	Missed primary
Phase 2	NCT00330993	Mar → Aug 2006	—	University of Pittsburgh	Completed	No outcome recorded
Phase 2	NCT00325026	Apr 2005 → Apr 2007	cervix disorder	University of Florida	Completed	No outcome recorded
Phase 2	NCT00393731	Jan 2004 → Aug 2007	—	The University of Texas Health Science Center, Houston	Completed	No outcome recorded
Phase 2	NCT00346840	Jun 2003 → Feb 2004	cervix disorder	Ferring Pharmaceuticals	Completed	No outcome recorded
Phase 2	NCT00310921	May 2001 → May 2006	—	Kaiser Permanente	Completed	No outcome recorded
Phase 2	NCT00107874	Jan 1999 → Feb 2002	—	University Hospital, Basel, Switzerland	Completed	No outcome recorded
Phase 2	NCT00528255	—	cervix disorder	Ferring Pharmaceuticals	Withdrawn	No outcome recorded

Phase 2/311 trials · 2 met primary
Phase 2/3	NCT07576881	Jun 2026 → Dec 2027 expected	pregnancy disorder	Indiana University	Not yet recruiting	No outcome recorded
Phase 2/3	NCT05957666	Jun → Dec 2023	—	Services Institute of Medical Sciences, Pakistan	Unknown	No outcome recorded
Phase 2/3	NCT02901561	Sep → Dec 2016	—	Assiut University	Completed	No outcome recorded
Phase 2/3	NCT04270994	Sep 2016 → Aug 2019	endometrial polyp	Henry Aristoteles Mate-Sánez	Completed	No outcome recorded
Phase 2/3	NCT02509351	Oct 2015 → Nov 2016	—	Ain Shams University	Completed	No outcome recorded
Phase 2/3	NCT02299401	Dec 2014 → Oct 2016	pregnancy disorder	Gynuity Health Projects	Completed	Met primary
Phase 2/3	NCT02141321	May 2014 → Jan 2015	—	Ain Shams University	Completed	No outcome recorded
Phase 2/3	NCT02083107	Feb 2013 → Feb 2014	—	Ain Shams University	Completed	No outcome recorded
Phase 2/3	NCT01477840	Aug 2012	—	Soudabeh Eshghi ali	Unknown	Met primary
Phase 2/3	NCT01615224	May 2012 → Oct 2019	pregnancy disorder with abortive outcome	Kristina Gemzell Danielsson	Terminated	No outcome recorded Stop: Business
Phase 2/3	NCT00148473	Mar 2000 → Oct 2001	hypertension, pregnancy-induced	Bangkok Metropolitan Administration Medical College and Vajira Hospital	Completed	No outcome recorded

Phase 339 trials · 3 met primary · 2 missed
Phase 3	NCT07506512	Jul 2027 → Jul 2031 expected	pregnancy loss, recurrent, 4	University of Pennsylvania	Not yet recruiting	No outcome recorded
Phase 3	NCT05245227	Jan 2025 → Jan 2027 expected	—	Stony Brook University	Recruiting	No outcome recorded
Phase 3	NCT06078501	Feb → Jul 2024	—	Stanford University	Terminated	No outcome recorded Stop: Enrollment
Phase 3	NCT05839899	Aug 2023 → Jul 2024	—	Planned Parenthood League of Massachusetts	Unknown	No outcome recorded
Phase 3	NCT05424445	Jan → Dec 2022	—	Karolinska Institutet	Completed	No outcome recorded
Phase 3	NCT04635007	Jan 2021 → Jun 2022	—	Cairo University	Completed	No outcome recorded
Phase 3	NCT04560218	Oct 2020 → Jul 2021	—	Department of Medical Services Ministry of Public Health of Thailand	Completed	No outcome recorded
Phase 3	NCT04339348	Apr 2020 → Feb 2021	—	Cairo University	Completed	No outcome recorded
Phase 3	NCT04152317	Nov 2019 → Sep 2020	cervix disorder	Professor Fernando Figueira Integral Medicine Institute	Completed	Missed primary
Phase 3	NCT05108597	Mar 2019 → Mar 2020	leiomyoma	Pak Emirates Military Hospital	Completed	No outcome recorded
Phase 3	NCT05761418	Mar 2018 → Feb 2023	leiomyoma	Beni-Suef University	Completed	No outcome recorded
Phase 3	NCT03483142	Nov 2017 → Jul 2018	leiomyoma	ahmed nagy shaker ramadan	Unknown	No outcome recorded
Phase 3	NCT03148574	Jul 2017 → Sep 2019	—	Assiut University	Completed	No outcome recorded
Phase 3	NCT03269279	May 2017 → Dec 2019	—	Gynuity Health Projects	Unknown	No outcome recorded
Phase 3	NCT02985229	Oct 2016 → Jul 2017	—	Gynuity Health Projects	Completed	No outcome recorded
Phase 3	NCT02758340	Apr → Nov 2016	—	Karachi Medical and Dental College	Completed	No outcome recorded
Phase 3	NCT02686840	Jan 2016 → Jan 2017	pregnancy disorder with abortive outcome	Ain Shams University	Completed	Met primary
Phase 3	NCT02163616	Sep 2015 → May 2016	—	Gynuity Health Projects	Completed	No outcome recorded
Phase 3	NCT02265562	Oct 2014 → May 2015	—	Cairo University	Unknown	No outcome recorded
Phase 3	NCT02036437	Sep 2013 → Sep 2014	indomethacin embryofetopathy	Ain Shams University	Unknown	No outcome recorded
Phase 3	NCT01710566	Jul 2013 → Dec 2014	—	Gynuity Health Projects	Withdrawn	No outcome recorded
Phase 3	NCT02061657	Jun 2013 → Jun 2014	leiomyoma	Ain Shams University	Completed	Met primary
Phase 3	NCT01795599	May 2013 → Feb 2015	—	Assistance Publique Hopitaux De Marseille	Unknown	No outcome recorded
Phase 3	NCT01805115	Mar 2013 → Jan 2014	endometrial disorder	CHA University	Completed	Met primary
Phase 3	NCT01866241	Nov 2012 → Sep 2013	—	Mbarara University of Science and Technology	Completed	Missed primary
Phase 3	NCT01428037	Mar 2012 → Jan 2013	cervix disorder	Regenex Pharmaceutical, China	Completed	No outcome recorded
Phase 3	NCT01127581	Sep 2010 → Mar 2012	cervix disorder	Ferring Pharmaceuticals	Completed	No outcome recorded
Phase 3	NCT00920465	Jun 2009 → Dec 2011	—	Western Galilee Hospital-Nahariya	Unknown	No outcome recorded
Phase 3	NCT01024270	Jul 2008 → Jul 2009	—	Samsung Medical Center	Completed	No outcome recorded
Phase 3	NCT01156948	May 2008 → Aug 2010	cervix disorder	Wenzhou Medical University	Unknown	No outcome recorded
Phase 3	NCT01373359	Mar 2007 → Jan 2008	—	Jawaharlal Nehru Medical College	Completed	No outcome recorded
Phase 3	NCT00363389	Sep 2006 → May 2007	uterine disorder	Ullevaal University Hospital	Completed	No outcome recorded
Phase 3	NCT00308711	Apr 2006 → Aug 2007	cervix disorder	Ferring Pharmaceuticals	Completed	No outcome recorded
Phase 3	NCT00529295	Jun 2005 → Mar 2007	—	China Medical University Hospital	Completed	No outcome recorded
Phase 3	NCT00602095	Dec 2004 → Mar 2007	pregnancy disorder	Karolinska University Hospital	Completed	No outcome recorded
Phase 3	NCT01116050	Jan 2004 → Dec 2007	—	University Hospital, Caen	Completed	No outcome recorded
Phase 3	NCT00140114	Jan 2004 → Sep 2006	—	American University of Beirut Medical Center	Completed	No outcome recorded
Phase 3	NCT00299754	Jan 2003 → Dec 2004	—	KK Women's and Children's Hospital	Completed	No outcome recorded
Phase 3	NCT03489928	Apr 1999 → Dec 2000	—	David Young	Completed	No outcome recorded

Phase 454 trials · 4 met primary · 8 missed
Phase 4	NCT07671989	Jun → Dec 2026 expected	menstrual disorder	University of California, San Francisco	Recruiting	No outcome recorded
Phase 4	NCT07286188	Dec 2025 → Dec 2026 expected	leiomyoma	Northwestern University	Recruiting	No outcome recorded
Phase 4	NCT07174856	Oct 2025 → Jan 2027 expected	—	Ibis Reproductive Health	Not yet recruiting	No outcome recorded
Phase 4	NCT06049745	Nov 2023 → Aug 2026 overdue	submucous uterine fibroid	Assuta Ashdod Hospital	Not yet recruiting	No outcome recorded
Phase 4	NCT05119439	Oct 2022 → Jun 2023	—	Gynuity Health Projects	Terminated	No outcome recorded Stop: Enrollment
Phase 4	NCT05262738	Jun 2022 → Jul 2023	obesity disorder, pregnancy disorder	University of Texas at Austin	Completed	Missed primary
Phase 4	NCT05124314	Oct 2021 → Oct 2023	—	Clinical Hospital Merkur	Unknown	No outcome recorded
Phase 4	NCT04940013	Oct 2021 → Sep 2025	menstrual disorder	University of California, San Francisco	Terminated	No outcome recorded Stop: Enrollment
Phase 4	NCT05046041	Nov 2020 → Aug 2021	—	Gynuity Health Projects	Completed	No outcome recorded
Phase 4	NCT03749902	Jan 2020 → Jul 2022	—	University of Liverpool	Completed	No outcome recorded
Phase 4	NCT04685694	Jan 2020 → Dec 2021	—	Tel-Aviv Sourasky Medical Center	Completed	Missed primary
Phase 4	NCT03829696	Jan 2020 → Jan 2021	—	University of California, San Francisco	Withdrawn	No outcome recorded
Phase 4	NCT04063904	Oct 2019 → Apr 2020	—	Gynuity Health Projects	Terminated	No outcome recorded Stop: Enrollment
Phase 4	NCT03670836	Nov 2018 → Jul 2021	—	Columbia University	Completed	Met primary
Phase 4	NCT03676621	Nov 2018 → Aug 2021	—	Assiut University	Completed	No outcome recorded
Phase 4	NCT03682718	Oct 2018 → Jan 2019	—	Ain Shams University	Completed	No outcome recorded
Phase 4	NCT03547778	Sep 2018 → Dec 2019	—	University of South Florida	Withdrawn	No outcome recorded
Phase 4	NCT03591913	Feb → Aug 2018	—	Assiut University	Completed	No outcome recorded
Phase 4	NCT03346629	Dec 2017 → Dec 2018	—	Gynuity Health Projects	Completed	No outcome recorded
Phase 4	NCT02777190	Nov 2017 → Apr 2019	pregnancy disorder	Milton S. Hershey Medical Center	Terminated	No outcome recorded Stop: Enrollment
Phase 4	NCT03815344	Apr 2017 → Jun 2019	leiomyoma	Antonios Likourezos	Completed	No outcome recorded
Phase 4	NCT02716142	Mar 2017 → Dec 2019	—	Assiut University	Completed	No outcome recorded
Phase 4	NCT02981030	Nov 2016 → Jun 2017	—	Gynuity Health Projects	Completed	No outcome recorded
Phase 4	NCT03134183	Nov 2016 → Aug 2017	—	Virginia Commonwealth University	Completed	No outcome recorded
Phase 4	NCT03064568	Oct 2016 → Jun 2024	—	The University of Texas Health Science Center at San Antonio	Completed	No outcome recorded
Phase 4	NCT02853552	Oct 2016 → Oct 2017	—	Gynuity Health Projects	Unknown	No outcome recorded
Phase 4	NCT02908295	Sep 2016 → Dec 2017	—	Department of Medical Services Ministry of Public Health of Thailand	Completed	No outcome recorded
Phase 4	NCT02745093	Sep → Dec 2016	—	Ibis Reproductive Health	Unknown	No outcome recorded
Phase 4	NCT02918110	Sep 2016 → Sep 2017	—	Karolinska Institutet	Unknown	Missed primary
Phase 4	NCT02704481	Jun 2016 → Jan 2019	—	Gynuity Health Projects	Terminated	No outcome recorded Stop: Business
Phase 4	NCT02762942	May 2016 → May 2017	cervix disorder, pregnancy disorder	Consorci Sanitari de Terrassa	Unknown	No outcome recorded
Phase 4	NCT02314754	Dec 2014 → Apr 2016	—	Gynuity Health Projects	Completed	No outcome recorded
Phase 4	NCT02732522	Oct 2014 → May 2015	cervix disorder	University of the Republic	Completed	Missed primary
Phase 4	NCT02226588	Oct 2014 → Jan 2016	—	Gynuity Health Projects	Completed	No outcome recorded
Phase 4	NCT02209545	Oct 2014 → Jul 2022	leiomyoma	Northwestern University	Terminated	No outcome recorded Stop: Enrollment
Phase 4	NCT02720991	Jul 2014 → Apr 2015	—	Gynuity Health Projects	Completed	No outcome recorded
Phase 4	NCT01856985	Apr → Sep 2013	—	Gynuity Health Projects	Completed	No outcome recorded
Phase 4	NCT01798017	Nov 2012 → Jun 2015	menstrual disorder	Gynuity Health Projects	Completed	No outcome recorded
Phase 4	NCT01620814	Jul → Aug 2012	cervix disorder	Zekai Tahir Burak Women's Health Research and Education Hospital	Unknown	No outcome recorded
Phase 4	NCT01519765	Jul 2011 → Dec 2014	pregnancy disorder	University of California, Los Angeles	Terminated	Missed primary Stop: Enrollment
Phase 4	NCT01549223	Apr 2011 → Jan 2012	hypotensive disorder, uterine disorder	Brigham and Women's Hospital	Completed	No outcome recorded
Phase 4	NCT01113229	Mar 2010 → Jul 2014	obstetric disorder	Assistance Publique - Hôpitaux de Paris	Terminated	Missed primary
Phase 4	NCT00997347	Jul 2009 → Feb 2012	—	Gynuity Health Projects	Completed	No outcome recorded
Phase 4	NCT00886860	May → Dec 2009	cervix disorder	Mahidol University	Completed	Missed primary
Phase 4	NCT01387256	May 2009 → Jul 2010	—	Gynuity Health Projects	Completed	No outcome recorded
Phase 4	NCT01733329	Feb 2008 → Dec 2013	—	Hospital Universitario Dr. Jose E. Gonzalez	Completed	Met primary
Phase 4	NCT01231126	Feb 2008 → Jan 2009	pregnancy disorder	Maternidade Escola Assis Chateaubriand	Completed	No outcome recorded
Phase 4	NCT00695331	Feb → Dec 2008	—	China Medical University Hospital	Unknown	Missed primary
Phase 4	NCT00129506	May → Sep 2005	—	Wiebe, Ellen, M.D.	Completed	No outcome recorded
Phase 4	NCT01700478	Feb → Apr 2005	hemorrhagic disease	University Hospital of the West Indies	Completed	Met primary
Phase 4	NCT00177372	Jan → Sep 2005	pregnancy disorder with abortive outcome	University of Pittsburgh	Completed	No outcome recorded
Phase 4	NCT00269568	Jun 2004 → Apr 2006	—	University of Pittsburgh	Completed	Met primary
Phase 4	NCT00190294	Apr 2003 → Sep 2006	pregnancy disorder	Assistance Publique - Hôpitaux de Paris	Completed	No outcome recorded
Phase 4	NCT00256009	? → Jan 2009	habitual spontaneous abortion	Rigshospitalet, Denmark	Unknown	No outcome recorded

Phase not applicable77 trials · 11 met primary · 7 missed
—	NCT07697781	Jan → Jul 2026 overdue	endometrial disorder	Faculty of Medicine of Tunis	Recruiting	No outcome recorded
—	NCT07559812	Oct 2025 → Apr 2026 overdue	cervix disorder, pregnancy disorder	Mayo Hospital Lahore	Active not recruiting	No outcome recorded
—	NCT06669533	Feb 2025 → Nov 2027 expected	cervical cancer	University of Alabama at Birmingham	Recruiting	No outcome recorded
—	NCT06850974	Feb 2025 → Mar 2027 expected	—	Stony Brook University	Recruiting	No outcome recorded
—	NCT07416487	Feb → Dec 2025	—	Muhammad Aamir Latif	Completed	No outcome recorded
—	NCT07534982	Jul 2024 → Jul 2027 expected	—	Yael Yagur	Recruiting	No outcome recorded
—	NCT07121634	Jan 2024 → Aug 2025 overdue	cervix disorder	Raid M. Al-Ani	Active not recruiting	No outcome recorded
—	NCT06060327	Oct 2023 → Jun 2024	—	Cairo University	Completed	No outcome recorded
—	NCT05532215	Mar → Oct 2023	—	OZORI EBIOGBO STANLEY	Unknown	No outcome recorded
—	NCT05696574	Jan → Jun 2023	pregnancy disorder	Cairo University	Unknown	No outcome recorded
—	NCT06726278	Aug 2022 → Jul 2024	cervix disorder	Hayat Abad Medical Complex, Peshawar	Completed	No outcome recorded
—	NCT05862428	Feb → Sep 2022	—	Queen Savang Vadhana Memorial Hospital, Thailand	Completed	No outcome recorded
—	NCT05094375	Nov 2021 → Mar 2023	pregnancy disorder with abortive outcome	hany farouk	Unknown	No outcome recorded
—	NCT05103098	Nov 2021 → Dec 2022	pregnancy disorder with abortive outcome	hany farouk	Unknown	No outcome recorded
—	NCT05088707	Nov 2021 → Dec 2022	pregnancy disorder with abortive outcome	Aswan University Hospital	Unknown	No outcome recorded
—	NCT05088720	Nov 2021 → Dec 2022	pregnancy disorder with abortive outcome	Aswan University Hospital	Unknown	No outcome recorded
—	NCT05077540	Nov 2021 → Oct 2023	—	Aswan University Hospital	Unknown	No outcome recorded
—	NCT04932382	Oct 2021 → Mar 2023	—	Assiut University	Completed	No outcome recorded
—	NCT05083910	Jul 2021 → Jan 2022	—	Bezmialem Vakif University	Completed	Met primary
—	NCT04887493	Jun → Nov 2021	—	Ministry of Health, Bhutan	Unknown	No outcome recorded
—	NCT06009679	Feb 2021 → Dec 2024	—	Assuta Ashdod Hospital	Unknown	No outcome recorded
—	NCT05857059	Oct 2019 → May 2024	obesity disorder, pregnancy disorder	Unidade Local de Saúde de Coimbra, EPE	Unknown	No outcome recorded
—	NCT03600064	Jul 2019 → Jul 2020	uterine inflammatory disease	Assiut University	Completed	No outcome recorded
—	NCT03748147	Dec 2018 → Jun 2020	indomethacin embryofetopathy	University of Cincinnati	Unknown	No outcome recorded
—	NCT03710317	Dec 2018 → May 2020	—	Aswan University Hospital	Completed	No outcome recorded
—	NCT03638856	Sep → Dec 2018	chronic pain syndrome, female infertility	Department of Medical Services Ministry of Public Health of Thailand	Completed	No outcome recorded
—	NCT03863392	Jun → Nov 2018	—	Ain Shams University	Unknown	No outcome recorded
—	NCT03440866	Mar 2018 → Dec 2021	—	HaEmek Medical Center, Israel	Unknown	Missed primary
—	NCT03148561	Jul 2017 → Jul 2019	pregnancy disorder with abortive outcome	Assiut University	Completed	Met primary
—	NCT03518463	Jun → Jul 2017	pregnancy disorder	Mbarara University of Science and Technology	Completed	No outcome recorded
—	NCT03043014	Jun 2017 → Mar 2019	—	Assistance Publique Hopitaux De Marseille	Completed	Met primary
—	NCT03031353	Jan 2017 → May 2018	persistent tachypnoe of infancy, usual	Ain Shams University	Unknown	No outcome recorded
—	NCT02983591	Nov 2016 → Dec 2017	—	Makassed General Hospital	Completed	No outcome recorded
—	NCT03239327	Jun 2016 → Jan 2018	newborn respiratory distress syndrome	Assiut University	Unknown	No outcome recorded
—	NCT02707653	Mar → Nov 2016	pregnancy disorder with abortive outcome	Gynuity Health Projects	Completed	No outcome recorded
—	NCT02581761	Nov 2015 → Nov 2017	—	Sheba Medical Center	Unknown	No outcome recorded
—	NCT02279914	Nov 2014 → Aug 2016	—	Planned Parenthood of Greater New York	Completed	No outcome recorded
—	NCT02013960	Jan → Dec 2014	—	Rambam Health Care Campus	Unknown	No outcome recorded
—	NCT01818414	Oct 2013 → Mar 2014	—	University of Pittsburgh	Terminated	Missed primary
—	NCT01916681	May 2013 → Jun 2015	—	University of Pennsylvania	Completed	Met primary
—	NCT01762319	Nov 2012 → Jun 2013	—	Mahidol University	Unknown	No outcome recorded
—	NCT01713153	Jun 2012 → Jan 2014	—	Gynuity Health Projects	Completed	Missed primary
—	NCT02411916	Mar 2012 → Feb 2019	—	New York City Health and Hospitals Corporation	Completed	No outcome recorded
—	NCT01508143	Jan → Sep 2012	—	Hormozgan University of Medical Sciences	Completed	No outcome recorded
—	NCT01462422	Dec 2011 → Mar 2014	—	Gynuity Health Projects	Completed	No outcome recorded
—	NCT01475318	Oct 2011 → Jun 2012	—	The University of Hong Kong	Unknown	No outcome recorded
—	NCT01939457	Sep 2011 → Aug 2012	pregnancy disorder with abortive outcome	Gynuity Health Projects	Completed	No outcome recorded
—	NCT01422226	Jul 2011 → Feb 2012	—	University of Colorado, Denver	Terminated	No outcome recorded Stop: Enrollment
—	NCT01307111	Feb 2011 → Feb 2013	—	University of New Mexico	Completed	No outcome recorded
—	NCT01147497	Jun 2010 → Sep 2011	—	Emory University	Completed	No outcome recorded
—	NCT01070472	Mar 2010 → Jun 2011	—	University of Manitoba	Completed	No outcome recorded
—	NCT01080846	Feb → Aug 2010	—	Gynuity Health Projects	Completed	Met primary
—	NCT02398838	Dec 2009 → Apr 2012	—	Gynuity Health Projects	Completed	No outcome recorded
—	NCT01001897	Oct 2009 → Jan 2011	—	University of Arizona	Completed	Missed primary
—	NCT01139801	Sep 2009 → Mar 2010	—	Aultman Health Foundation	Completed	No outcome recorded
—	NCT01173003	Jun 2009 → Dec 2011	—	Gynuity Health Projects	Completed	No outcome recorded
—	NCT00969982	Jun 2009 → Jun 2013	—	Gynuity Health Projects	Completed	Met primary
—	NCT00886834	Apr 2009 → Mar 2011	—	University of Utah	Completed	Missed primary
—	NCT01689311	Mar 2009 → Aug 2011	—	Samuel Lunenfeld Research Institute, Mount Sinai Hospital	Completed	Met primary
—	NCT00835731	Jan 2009 → Dec 2011	cervix disorder	Planned Parenthood League of Massachusetts	Completed	Missed primary
—	NCT01033903	Oct 2008 → Dec 2015	habitual spontaneous abortion	Region Skane	Completed	Met primary
—	NCT01718314	Mar 2008 → Dec 2009	—	Dr. Sami Ulus Children's Hospital	Completed	No outcome recorded
—	NCT00797693	Jan → May 2008	pregnancy disorder with abortive outcome	Hawler Medical University	Completed	No outcome recorded
—	NCT00680394	Jul 2007 → May 2008	—	Gynuity Health Projects	Completed	Met primary
—	NCT00613366	Jun 2007 → Apr 2010	—	Oregon Health and Science University	Completed	No outcome recorded
—	NCT00468299	Apr 2007 → Dec 2008	pregnancy disorder with abortive outcome	Boston University	Terminated	No outcome recorded Stop: Enrollment
—	NCT00495560	Jan → Jul 2007	—	Boston University	Completed	No outcome recorded
—	NCT00386867	Oct 2006 → Mar 2007	—	Gynuity Health Projects	Completed	Met primary
—	NCT00386282	Sep 2006 → Mar 2011	—	Gynuity Health Projects	Completed	No outcome recorded
—	NCT00674232	May 2006 → Oct 2007	pregnancy disorder with abortive outcome	Gynuity Health Projects	Completed	No outcome recorded
—	NCT00116480	Dec 2005 → Apr 2007	—	Gynuity Health Projects	Completed	No outcome recorded
—	NCT00124540	Aug 2005 → Sep 2007	—	Gynuity Health Projects	Completed	Missed primary
—	NCT00116350	Jul 2005 → Jan 2008	—	Gynuity Health Projects	Completed	No outcome recorded
—	NCT00120237	Jul 2005 → Jul 2008	anemia	Gynuity Health Projects	Completed	No outcome recorded
—	NCT00097123	Sep 2002 → Dec 2005	pregnancy disorder	NICHD Global Network for Women's and Children's Health	Completed	Met primary
—	NCT00385229	Sep 2002 → Dec 2003	perinatal disease	St. Olavs Hospital	Completed	No outcome recorded
—	NCT01487278	—	—	Gynuity Health Projects	Withdrawn	No outcome recorded

Comparator or background therapy228 trials
Phase 0	NCT07109258 Comparator	May → Sep 2025 overdue	—	Cairo University	Recruiting	No outcome recorded
Phase 0	NCT06207539 Background	Dec 2022 → Mar 2023	—	Ain Shams Maternity Hospital	Completed	No outcome recorded
Phase 0	NCT05342974 Background	Apr 2022 → Dec 2023	—	University of Utah	Completed	No outcome recorded
Phase 0	NCT05001061 Comparator	Aug → Oct 2021	pregnancy disorder with abortive outcome	Cairo University	Unknown	No outcome recorded
Phase 0	NCT04478942 Comparator	Oct 2020 → Jan 2025	preterm premature rupture of the membranes	University of Wisconsin, Madison	Completed	No outcome recorded
Show all 228 trials opens the full record — a long page

News releases announcing trial results or a regulatory action · 2

Date	Issuer	Release
2020-08-17	Norgine	Regulatory Norgine B.V. completes important regulatory milestone for ANGUSTA® (misoprostol) in Europe for oral induction of labour norgine.com ↗ The procedure has been concluded by the Danish Regulatory Authority, the Reference Member State for the assessment.
2019-07-03	Zydus Lifesciences Limited	Regulatory Misoprostol Tablets zyduslife.com ↗ Zydus Cadila has received the final approval from the USFDA to market Misoprostol Tablets (US RLD – Cytotec®), 100 mcg and 200 mcg.

All press releases naming this drug 2 releases

Date	Issuer	Release
2020-08-17	Norgine	Norgine B.V. completes important regulatory milestone for ANGUSTA® (misoprostol) in Europe for oral induction of labour norgine.com ↗
2019-07-03	Zydus Lifesciences Limited	Misoprostol Tablets zyduslife.com ↗

Evidence & citations 18 cited values

Every value below carries the sentence it was read from. 452 sources stand behind the page.

Field	Value	Cited text
Known as	Misoprostol	“In Misoprostol group (n=111), 400 microgram misoprostol (2 tablets - Cytotec, Pfizer, G.D. Searle LLC) will be inserted intraoperative inside the uterus after delivery of the placenta” NCT06060327 ↗ 444 “OBJECTIVE: To compare the efficacy and safety of a 200-microgram misoprostol vaginal insert with a 10-mg dinoprostone vaginal insert for reducing the time to vaginal delivery.” PMID 23857539 ↗ Aug 2013 “Misoprostol, a prostaglandin E1 analogue, is the most interesting alternative to Dinoprostone because of its effectiveness, low cost, and temperature stability.” NCT02036437 ↗ “A tablet of DA9601, Cytotec (200ug of Misoprostol), Acrofen (100mg of Aceclofenac) will be assigned randomly to the subjects for four weeks.” NCT01912066 ↗ “800 micrograms misoprostol vaginally followed by 400 micrograms oral misoprostol every 3 hours with a maximum of four oral doses.” PMID 24084539 ↗ Oct 2013 “Recent evidence however has shown that misoprostol is associated with better outcomes and merits evaluation in our environment.” NCT06343480 ↗ “misoprostol tablet (400 mg) was placed into uterine cavity at the fundus after delivery of the placenta and swabbing the cavity” NCT05083910 ↗ “the recommended use of mifepristone or misoprostol as cervical preparation for the abortions after 12 weeks” NCT01795599 ↗ “Letrozole 2.5 mg each 12 hours for 2 days followed by vaginal misoprostol 800 mcg for induction of abortion” NCT04590482 ↗ “The first regimen will include a 200 mg oral dose of mifepristone followed by 800 mcg buccal misoprostol.” NCT01387256 ↗ “Dose reservoir of 100 mcg of misoprostol in a hydrogel polymer vaginal insert within a retrieval system.” NCT00828711 ↗ Show 434 more sources
Known as	Angusta	“A Comparative, Open-label, Parallel Design, Bioavailability Study of Two Misoprostol Formulations (Angusta™ 25 µg Dispersible Tablets vs. Cytotec® 200 µg Tablets) Following...” NCT02516631 ↗ 2 “Oral misoprostol (ANGUSTA®) 25 µg every 2 hours, 8 times (maximum dosage should not exceed 200µg).” NCT04949633 ↗ “Norgine (who make Angusta, a 25 µg oral misoprostol tablet).” PMID 34155622 ↗ Jun 2021
Known as	Cytotec	“A Comparative, Open-label, Parallel Design, Bioavailability Study of Two Misoprostol Formulations (Angusta™ 25 µg Dispersible Tablets vs. Cytotec® 200 µg Tablets) Following...” NCT02516631 ↗ 17 “In Misoprostol group (n=111), 400 microgram misoprostol (2 tablets - Cytotec, Pfizer, G.D. Searle LLC) will be inserted intraoperative inside the uterus after delivery of the placenta” NCT06060327 ↗ “Patients assigned to PO Misoprostol (Cytotec) 400 mg once, 2-4 hours prior to hysteroscopy” NCT02474433 ↗ “misoprostol (Cytotec tables; Searle,A Division of Monsanto.P.L.C, England )0.8mg orally” NCT00677755 ↗ “only vaginal Misoprostol 800mcg (4 tablets Cytotec 200mcg ) ) every 3 hours” NCT04981457 ↗ “Misoprostol (Cytotec) is used widely in Obstetrics and Gynecology” NCT06009679 ↗ “800 µg sublingual misoprostol (Cytotec Pfizer, New York, USA)” NCT05077540 ↗ “Misoprostol (Cytotec; GD Searle and Co., Chicago, IL)” NCT00426491 ↗ “Misoprostol ( Cytotec) 200 microgram a tablet” NCT00797693 ↗ “Misoprostol ( Cytotec) 200 microgram a tablet” NCT07697781 ↗ “Misoprostol ( Cytotec) 200 microgram a tablet” NCT07465016 ↗ Show 7 more sources
Known as	Cytotec (brand name)	“Cytotec (brand name)” NCT04768010 ↗
Known as	Misodel	“vaginal slow release misoprostol (Misodel®)” NCT02918110 ↗
Known as	Misoprostol (Cytotec)	“Misoprostol (Cytotec)” NCT01933360 ↗
Known as	Misoprostol is also known as Cytotec	“Misoprostol is also known as Cytotec” NCT01916681 ↗
Known as	Misoprostol Vaginal Insert	“Misoprostol Vaginal Insert (MVI 100)” NCT00528255 ↗
Known as	Misotac	“In the misoprostol group (n = 183), sublingual misoprostol was given by putting two moistened tablets of misoprostol (400 µg) under the tongue and allowing them to dissolve...” NCT01466530 ↗ 11 “Women will receive vaginally one tablet misoprostol 200 mcg(Misotac; Sigma Pharma, SAE, EGYPT) plus one tablet isosorbide mononitrate 40 mg(Effox 40 mg; Minapharm).” NCT03587077 ↗ “misoprostol (misotac® sigma pharmaceutical industries) 200 mcg vaginally applied ten and four hours prior to the second attempt of IUD insertion” NCT03790371 ↗ “Misoprostol group (M) received 2 rectal misoprostol tablets (800 μg) (Misotac; SIGMA Pharm, Cairo, Egypt) after the delivery of the baby.” NCT03556852 ↗ “women will receive misoprostol 100 mcg (Misotac, Sigma Pharmaceuticals, Egypt) vaginally applied every 6 hours till cervical dilatation.” NCT03584698 ↗ “1 vaginal tablet of misoprostol (200mcg) (Misotac®; Sigma Pharma, SAE, Egypt) inserted by the study nurse 3 hours before IUD insertion.” NCT04080336 ↗ “the women will be received two tablets of misoprostol 400 mcg vaginally before IUD removal (Misotac®; Sigma Pharma, SAE, Egypt).” NCT03600064 ↗ “800μg rectal misoprostol (Misotac®, SIGMA, Egypt) immediately after urinary catheterization and before skin incision” NCT04635007 ↗ “received misoprostol 800 µg (Misotac 200 µg tablets, SIGMA pharmaceutical) once dose vaginally” NCT03148561 ↗ “1 vaginal tablet of misoprostol (200 mcg) (Misotac®; Sigma Pharma, SAE, Egypt)” NCT04080349 ↗ “two intrauterine misoprostol tablets (Misotac® 200microgram, Sigma Ph., Egypt)” NCT06364098 ↗ Show 1 more source
Known as	Misotac (Misoprostol)	“Misotac (Misoprostol)” NCT02036437 ↗
Known as	Misotac 200 µg tablets	“received misoprostol 800 µg (Misotac 200 µg tablets, SIGMA pharmaceutical) once dose sublingually” NCT05088720 ↗
Known as	MVI	“Women enrolled into the Phase III trial, EXPEDITE (clinical trial registration: NCT01127581), had labour induced with either a misoprostol or dinoprostone vaginal insert (MVI or DVI).” PMID 25758619 ↗ Mar 2015
Known as	MVI 100	“Misoprostol Vaginal Insert (MVI 100)” NCT00528255 ↗
Known as	PGE1	“misoprostol (PGE1) 200ug” NCT02738177 ↗
Known as	Prostaglandin E2	“Introduction: The study aimed to investigate the effectiveness of a single versus double dose of Prostaglandin E2 "Misoprostol, 400 microgram" during myomectomy for multiple...” NCT02154932 ↗
Known as	Vagiprost	“Pregnant women had taken misoprostol (vagiprost vaginal tablet; Adwia Pharmaceutical Company) vaginally as 25 micro gram of misoprostol.” NCT04514770 ↗ 2 “vaginal misoprostol 25 μg (Vagiprost) tablets with vaginal estradiol 150 ml cream will be applied for induction of laour” NCT05306405 ↗ “followed by intravaginal 25mcg of misoprostol (Vagiprost)” NCT03523754 ↗
Modality	Other / unclassified	“misoprostol, an orally active prostaglandin” PMID 21130990 ↗ Dec 2010
Route	Oral	“misoprostol administered orally during the third stage of labor” NCT00097123 ↗