drugset / Trial / NCT05342974
Atorvastatin as a Potential Adjunct to Misoprostol for Termination of Pregnancy
NaSingle-groupOpen-labelOther
Summary
Medication abortion is a way of ending a pregnancy using pills. The current FDA-approved regimen for medication abortion uses mifepristone and misoprostol. This study is testing whether a different medication, atorvastatin, followed by misoprostol, can be used to end a pregnancy. Participants at 35-49 days of pregnancy will receive an oral dose of atorvastatin (80 mg) to swallow at the clinic as well as taking atorvastatin (80 mg) daily for six additional days, with a return to clinic on day 8 after initial visit to take a dose of misoprostol (800 mcg). Additionally, follow-up visits will occur on approximately days 3, 8 and 11 for a clinician to perform an ultrasound to see if the abortion is complete.
Timeline
- Start
- 2022-04-19
- Primary completion
- 2023-12-31
- Completion
- 2025-01-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Atorvastatin | Small molecule | 80 mg | Oral |
| Background | Misoprostol | Other / unclassified | 800 ug | Intravenous |
Indications
No indication recorded.