Dose Comparison of Misoprostol for Cervix Ripening Before Operative Hysteroscopy.

Summary

The medication misoprostol is used to facilitate the entry into the uterus of hysteroscopy surgery equipment and this research aims to compare the results of the use of this drug in two different doses trying to find the optimal one. To perform this work we will use the misoprostol and will perform a questionnaire that will be asked during hospitalization, before, during and the 12hours after the surgery. The patients who meet the inclusion criteria after signing the Informed Consent Form will be allocated into two groups getting misoprostol 200mcg or misoprostol 800mcg.

Timeline

Start

2019-11-07

Primary completion

2020-09-11

Completion

2020-09-12

Outcome

Missed primary endpoint

paper There was no statistical difference between the groups in the mean of the cervical width PMID 34695232 ↗

paper P = 0.055 PMID 34695232 ↗

Publications

• Maior MDCFS, Souza ASR, Souza GFA, da Costa AAR. Comparison between 200 mug and 800 mug of vaginal misoprostol for cervical ripening before operative hysteroscopy: A randomized controlled trial. Int J Gynaecol Obstet. 2022 Jul;158(1):205-212. doi: 10.1002/ijgo.13984. Epub 2021 Nov 3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Misoprostol	Other / unclassified	200 ug	Intravenous
Subject	Misoprostol	Other / unclassified	800 ug	Intravenous

Indications