Treatment of Clozapine-Induced Hypersalivation Ipratropium Bromide

Completed 25 enrolled Centre for Addiction and Mental Health

RandomizedCrossoverDouble-blindTreatment

Summary

Hypersalivation (Too much saliva) and drooling is a side effect experienced by 31% of people taking the antipsychotic clozapine. This study aims to determine if using the medication ipratropium bromide(IPB)at bedtime will reduce the amount of salivation and the distress people may feel.

Timeline

Start: 2006-10
Primary completion: 2008-06
Completion: —

Publications

Sockalingam S, Shammi C, Remington G. Treatment of clozapine-induced hypersalivation with ipratropium bromide: a randomized, double-blind, placebo-controlled crossover study. J Clin Psychiatry. 2009 Aug;70(8):1114-9. doi: 10.4088/JCP.08m04495.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ipratropium	Small molecule	0.03 %	Other

Indications

No indication recorded.