Drugs / Ipratropium
last change Jun 2026 re-read 9 days ago

Ipratropium

Small molecule targets CHRM3 via inhibition

Developed for
chronic obstructive pulmonary disease · asthma · childhood onset asthma · acute asthma · acute lung injury · bronchitis · Parkinson disease · pulmonary arterial hypertension
+6 more · status asthmaticus · acute respiratory distress syndrome · acute respiratory failure · bronchiectasis · exercise-induced bronchoconstriction · Riley-Day syndrome
Investigated by
Boehringer Ingelheim · Assistance Publique - Hôpitaux de Paris · GlaxoSmithKline · Laval University · Neutec Ar-Ge San ve Tic A.Ş · Queen's University
+34 more · Wake Forest University Health Sciences · Centre for Addiction and Mental Health · Children's Hospital and Institute of Child Health, Multan · Cook Children's Health Care System · Dey · Dr. J. Alberto Neder · Federal University of Rio Grande do Norte · Guangzhou Panyu Central Hospital · Haukeland University Hospital · Institut universitaire de cardiologie et de pneumologie de Québec, University Laval · Kaiser Permanente · London Health Sciences Centre · MetroHealth Medical Center · Mylan Inc. · National Center for Advancing Translational Sciences (NCATS) · National Heart, Lung, and Blood Institute (NHLBI) · Oregon Health and Science University · Parkinson's Disease Foundation · Pneuma Respiratory, Inc · State University of New York at Buffalo · Sumitomo Pharma America, Inc. · The First Affiliated Hospital of Guangzhou Medical University · Theravance Biopharma · US Department of Veterans Affairs · University Health Network, Toronto · University Hospital, Geneva · University Hospital, Tours · University Hospitals Cleveland Medical Center · University at Buffalo · University of Monastir · University of Montreal · University of Utah · Verona Pharma, Inc. · Zhujiang Hospital

Regulatory milestones approvals, filings & regulatory actions · 4 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansions (3) US (FDA) ATROVENT — 1998-04-01 – 2000-10-27 fda.gov ↗
Approved US (FDA) ATROVENT — 1986-12-29 fda.gov ↗

Trials 64 · started per year

today
US approved 1986
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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT04617015 Sep 2016 → Mar 2019 childhood onset asthma, depressive disorder State University of New York at Buffalo Completed No outcome recorded
Phase 16 trials
Phase 1 NCT03480997 Dec 2016 → Apr 2017 chronic obstructive pulmonary disease Pneuma Respiratory, Inc Completed No outcome recorded
Phase 1 NCT02872597 Sep 2016 → Aug 2018 status asthmaticus University Hospitals Cleveland Medical Center Completed No outcome recorded
Phase 1 NCT02207452 Aug 2010 → Jul 2011 chronic obstructive pulmonary disease GlaxoSmithKline Completed No outcome recorded
Phase 1 NCT00549120 Aug → Oct 2007 chronic obstructive pulmonary disease GlaxoSmithKline Completed No outcome recorded
Phase 1 NCT02172781 Jan → Apr 2001 — Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT02173678 Oct → Nov 1999 — Boehringer Ingelheim Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT02755714 Jun 2016 → Oct 2020 — Haukeland University Hospital Completed No outcome recorded
Phase 212 trials · 2 met primary
Phase 2 NCT07394036 Jun 2026 → Dec 2029 expected — Cook Children's Health Care System Not yet recruiting No outcome recorded
Phase 2 NCT06074185 Jan 2024 → Feb 2025 childhood onset asthma Oregon Health and Science University Completed No outcome recorded
Phase 2 NCT03747536 Jan → Oct 2019 — London Health Sciences Centre Unknown No outcome recorded
Phase 2 NCT02542254 Oct → Dec 2015 chronic obstructive pulmonary disease Verona Pharma, Inc. Completed No outcome recorded
Phase 2 NCT03064113 May → Oct 2011 chronic obstructive pulmonary disease Mylan Inc. Completed Met primary
Phase 2 NCT00818454 Dec 2008 → Sep 2009 asthma Boehringer Ingelheim Completed Met primary
Phase 2 NCT00296946 Nov 2004 → Jun 2006 Parkinson disease University Health Network, Toronto Completed No outcome recorded
Phase 2 NCT00096616 Nov 2004 → Mar 2006 asthma Boehringer Ingelheim Completed No outcome recorded
Phase 2 NCT02182674 Oct 2000 → Aug 2001 chronic obstructive pulmonary disease Boehringer Ingelheim Completed No outcome recorded
Phase 2 NCT02236169 Oct 2000 → Apr 2001 chronic obstructive pulmonary disease Boehringer Ingelheim Completed No outcome recorded
Phase 319 trials · 1 met primary
Phase 3 NCT05890638 Aug 2023 → Feb 2024 chronic obstructive pulmonary disease Neutec Ar-Ge San ve Tic A.Ş Unknown No outcome recorded
Phase 3 NCT04446637 Sep 2021 → Sep 2022 chronic obstructive pulmonary disease Neutec Ar-Ge San ve Tic A.Ş Withdrawn No outcome recorded
Phase 3 NCT02782052 Jul 2016 → Oct 2018 pulmonary arterial hypertension Assistance Publique - Hôpitaux de Paris Withdrawn No outcome recorded
Phase 3 NCT01944033 Jul 2013 → Jul 2016 chronic obstructive pulmonary disease University of Monastir Completed No outcome recorded
Phase 3 NCT00462540 May → Sep 2007 chronic obstructive pulmonary disease Dey Completed Met primary
Phase 3 NCT00239434 Jun 2003 → Mar 2004 chronic obstructive pulmonary disease Boehringer Ingelheim Completed No outcome recorded
Phase 3 NCT02176187 Apr 2003 → Dec 2004 chronic obstructive pulmonary disease Boehringer Ingelheim Terminated No outcome recorded
Phase 3 NCT02176200 Apr 2003 → Dec 2004 chronic obstructive pulmonary disease Boehringer Ingelheim Terminated No outcome recorded
Phase 3 NCT02177253 Oct 2002 → Mar 2004 chronic obstructive pulmonary disease Boehringer Ingelheim Completed No outcome recorded
Phase 3 NCT02173795 Oct 2002 → Jun 2003 asthma, chronic obstructive pulmonary disease Boehringer Ingelheim Completed No outcome recorded
Phase 414 trials · 2 met primary
Phase 4 NCT06825013 Nov 2024 → Jan 2027 expected chronic obstructive pulmonary disease Dr. J. Alberto Neder Recruiting No outcome recorded
Phase 4 NCT06918418 Jan → Jun 2024 acute asthma Children's Hospital and Institute of Child Health, Multan Completed No outcome recorded
Phase 4 NCT03219866 Oct 2017 → Apr 2020 chronic obstructive pulmonary disease Wake Forest University Health Sciences Terminated No outcome recorded Stop: Enrollment
Phase 4 NCT01943552 Oct 2013 → Jul 2015 chronic obstructive pulmonary disease Boehringer Ingelheim Completed Met primary
Phase 4 NCT02103374 Jan 2012 → Dec 2015 chronic obstructive pulmonary disease University Hospital, Tours Completed No outcome recorded
Phase 4 NCT00388882 Oct 2006 → Oct 2007 chronic obstructive pulmonary disease Boehringer Ingelheim Completed No outcome recorded
Phase 4 NCT00359788 Jul 2006 → Apr 2008 chronic obstructive pulmonary disease Boehringer Ingelheim Completed Met primary
Phase 4 NCT00354354 Mar 2006 → Jul 2009 chronic obstructive pulmonary disease Queen's University Completed No outcome recorded
Phase 4 NCT00202176 Jul 2005 → Dec 2008 chronic obstructive pulmonary disease Queen's University Completed No outcome recorded
Phase 4 NCT02238210 Dec 2002 → May 2003 — Boehringer Ingelheim Completed No outcome recorded
Phase not applicable11 trials · 1 met primary · 1 missed
— NCT05786950 Jan → Jul 2023 chronic obstructive pulmonary disease The First Affiliated Hospital of Guangzhou Medical University Completed No outcome recorded
— NCT03071731 Apr 2017 → Jun 2019 chronic obstructive pulmonary disease Laval University Unknown No outcome recorded
— NCT03271905 Apr 2017 → Dec 2018 asthma, chronic obstructive pulmonary disease Federal University of Rio Grande do Norte Unknown No outcome recorded
— NCT02296047 Dec 2014 → May 2015 chronic obstructive pulmonary disease Zhujiang Hospital Completed No outcome recorded
— NCT03062904 Feb 2014 → Dec 2019 — Assistance Publique - Hôpitaux de Paris Unknown No outcome recorded
— NCT01655199 Sep 2012 → Jul 2014 chronic obstructive pulmonary disease Laval University Unknown No outcome recorded
— NCT00381589 Oct 2006 → Jun 2008 — Centre for Addiction and Mental Health Completed Missed primary
— NCT00498251 Sep 2004 → Jun 2007 acute lung injury University Hospital, Geneva Completed No outcome recorded
— NCT00583778 Aug 2004 → Nov 2008 asthma MetroHealth Medical Center Completed Met primary
— NCT00371527 Oct 2002 → Jan 2004 bronchitis Kaiser Permanente Completed No outcome recorded
Comparator or background therapy37 trials
Phase 1/2 NCT06657079 Comparator May 2024 → Jan 2025 acute respiratory distress syndrome Damanhour University Completed No outcome recorded
Phase 2 NCT04315558 Comparator Nov 2020 → Jan 2025 acute respiratory failure, chronic obstructive pulmonary disease University of California, Los Angeles Completed No outcome recorded
Phase 2 NCT01426009 Comparator Aug → Dec 2011 chronic obstructive pulmonary disease Sunovion Respiratory Development Inc. Completed Met primary
Phase 2 NCT01350128 Comparator May → Oct 2011 chronic obstructive pulmonary disease Pearl Therapeutics, Inc. Completed Met primary
Phase 2 NCT00117182 Background Jul 2005 → Aug 2006 chronic obstructive pulmonary disease Syntara Completed No outcome recorded

Evidence & citations 31 cited values

Every value below carries the sentence it was read from. 102 sources stand behind the page.

FieldValueCited text
Known as ipratropium “Group Terbutaline/Ipratropium Bromide received combination of 5 mg Terbutaline (2ml) and 0.5 mg Ipratropium bromide (2ml) and 1ml serum saline in nebulization repeated threeand...” NCT01944033 ↗
49

“50 µg Fenoterol Hydrobromide/20 µg Ipratropium Bromide and 25 µg Fenoterol Hydrobromide/10 µg Ipratropium Bromide, 1 Puff q.i.d” NCT02173782 ↗

“Test of Bronchodilatation (combined Salbutamol 200μg and Ipratropium bromure 80μg; 2 inhalations): wait 30 min and then” NCT03062904 ↗

“Participants will be administered aerosolized budesonide and ipratropium or a placebo every eight hours for five days.” NCT06657079 ↗

“50 µg Fenoterol Hydrobromide/20 µg Ipratropium Bromide and 25 µg Fenoterol Hydrobromide/10 µg Ipratropium Bromide” NCT02182479 ↗

“comparing the fixed combination of ipratropium and albuterol (IB+ALB) to albuterol alone (ALB).” PMID 18403223 ↗ Mar 2008

“All subjects receive inhaled ipratropium once with measurement of spirometry before and after.” NCT04617015 ↗

“0.5 mg ipratropium bromide + 2.5 mg salbutamol will be inhaled via nebulizer” NCT03405090 ↗

“anticholinergic agents (ipratropium and oxitropium bromide)” NCT02515318 ↗

“anticholinergic agents (ipratropium and oxitropium bromide)” NCT02509299 ↗

“fenoterol hydrobromide 50μg + ipratropium bromide 20μg” NCT02176187 ↗

Show 39 more sources

Known as ATROVENT “An Open-Label, Crossover, Pharmacokinetic Trial to Determine the Comparability of 84 µg Ipratropium Bromide HFA-134a Inhalation Aerosol to 84 µg ATROVENT® CFC Inhalation...” NCT02236169 ↗
13

“To evaluate acute effect of single dose of ipratropium (Atrovent) or fenoterol (Berotec) in comparison to placebo when given to COPD patients on pharmacodynamic steady state of...” NCT00274066 ↗

“The objective of this study was to compare the bronchodilator efficacy and safety of ipratropium bromide HFA-134a inhalation aerosol and marketed, Atrovent® CFC Inhalation...” NCT02260011 ↗

“Nebulized bronchodilator drugs will be Salbutamol Sulfate (aerolin nebulis) and ipratropium bromide (atrovent) diluted in a saline solution (saline 0.9%) in 3 ml.” NCT03271905 ↗

“Bronchodilator Treatment: Subjects will inhale 1 unit dose vial of aerosolized ipratropium (500 mcg of ipratropium (Atrovent) mixed in 2.5 ml of saline).” NCT00904436 ↗

“20 mcg and 40 mcg of Ipratropium Bromide, as delivered by the RESPIMAT Device, to 18 mcg ATROVENT® Inhalation Aerosol” NCT02177344 ↗

“Ipratropium Bromide (Atrovent) & Albuterol (Ventolin) as Standard of Care” NCT04655170 ↗

“Atrovent? MDI (2 puffs of ipratropium bromide 20 ?g four times daily)” NCT00239434 ↗

“(Atrovent ®)” NCT01987219 ↗

NCT02172443 ↗

NCT00274092 ↗

Show 3 more sources

Known as Atrovent aerocaps ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597 ↗
Known as Atrovent fte ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597 ↗
Known as Atrovent HFA “Ipratropium bromide (Atrovent® HFA) is a short acting anticholinergic bronchodilator (short acting muscarinic antagonist (SAMA)) that improves lung function, dyspnea, exercise...” NCT00911651 ↗
Known as Atrovent udvs ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597 ↗
Known as AtroventTM “ipratropium (AtroventTM 20 µg/inhalation, 2 inhalations four times daily)” NCT01415518 ↗
Known as Bromure d'ipratropium ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597 ↗
Known as Bromuro de ipratropio ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597 ↗
Known as Ipratrop ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597 ↗
Known as Ipratrop steripoule ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597 ↗
Known as ipratropium bromide “Study to demonstrate the comparability of two puffs of Combivent hydrofluoroalkane (HFA) inhalation aerosol (18 mcg ipratropium bromide/100 mcg albuterol sulfate / per puff) to...” NCT02182674 ↗
55

“Study to compare the lung and oropharyngeal deposition of Berodual® (fenoterol hydrobromide 50μg + ipratropium bromide 20μg /1x puff) delivered via the Respimat® inhaler and...” NCT02176200 ↗

“This study's objective was to evaluate whether ipratropium bromide/albuterol metered-dose inhaler (CVT-MDI) provides more effective acute relief of bronchospasm in...” PMID 27130202 ↗ Apr 2016

“Nebulized bronchodilator drugs will be Salbutamol Sulfate (aerolin nebulis) and ipratropium bromide (atrovent) diluted in a saline solution (saline 0.9%) in 3 ml.” NCT03271905 ↗

“the simultaneous administration of ipratropium bromide hydrofluoroalkane (HFA; I) and albuterol HFA (A) metered-dose inhalers as dual monotherapies (I + A).” PMID 23658479 ↗ Mar 2013

“The bronchodilator consisted of ipratropium bromide prescribed three times daily, two puffs per time, from a metered-dose inhaler.” NCT00000568 ↗

“inhaled compound ipratropium bromide solution (3mg salbutamol and 500μg ipratropium, Boehringer Ingelheim Limited, Germany)” NCT05786950 ↗

“Nebulization of ipratropium bromide/salbutamol sulfate (500 µg/2.5 mg) before the administration of the Glittre ADL-test” NCT03071731 ↗

“Berodual® Respimat® (20 µg ipratropium bromide + 50 µg fenoterol hydrobromide per actuation for 49 days)” NCT02173795 ↗

“0.5 mg ipratropium bromide + 2.5 mg salbutamol will be inhaled via nebulizer” NCT03405090 ↗

“Ipratropium Bromide (Atrovent) & Albuterol (Ventolin) as Standard of Care” NCT04655170 ↗

Show 45 more sources

Known as Ipratropium bromide anhydrous ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597 ↗
Known as Ipratropium bromide component of combivent ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597 ↗
Known as Ipratropium bromide component of duoneb ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597 ↗
Known as Ipratropium bromide component of duovent ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597 ↗
Known as Ipratropium bromide hydrate ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597 ↗
Known as Ipratropium bromide monohydrate ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597 ↗
Known as Ipratropium cation ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597 ↗
Known as Ipratropium ion ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597 ↗
Known as NSC-759613 ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597 ↗
Known as Respontin ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597 ↗
Known as Rinatec ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597 ↗
Known as SCH 1000-BR-MONOHYDRATE ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597 ↗
Known as SCH-1000-BR- ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597 ↗