Drugs / Ipratropium
last change Jun 2026 re-read 2 minutes ago

Ipratropium

Small molecule targets CHRM3 via inhibition

Developed for
chronic obstructive pulmonary disease · asthma · childhood onset asthma · acute asthma · acute lung injury · bronchitis · Parkinson disease · pulmonary arterial hypertension
+6 more · status asthmaticus · acute respiratory distress syndrome · acute respiratory failure · bronchiectasis · exercise-induced bronchoconstriction · Riley-Day syndrome
Investigated by
Boehringer Ingelheim · Assistance Publique - Hôpitaux de Paris · GlaxoSmithKline · Laval University · Neutec Ar-Ge San ve Tic A.Ş · Queen's University
+34 more · Wake Forest University Health Sciences · Centre for Addiction and Mental Health · Children's Hospital and Institute of Child Health, Multan · Cook Children's Health Care System · Dey · Dr. J. Alberto Neder · Federal University of Rio Grande do Norte · Guangzhou Panyu Central Hospital · Haukeland University Hospital · Institut universitaire de cardiologie et de pneumologie de Québec, University Laval · Kaiser Permanente · London Health Sciences Centre · MetroHealth Medical Center · Mylan Inc. · National Center for Advancing Translational Sciences (NCATS) · National Heart, Lung, and Blood Institute (NHLBI) · Oregon Health and Science University · Parkinson's Disease Foundation · Pneuma Respiratory, Inc · State University of New York at Buffalo · Sumitomo Pharma America, Inc. · The First Affiliated Hospital of Guangzhou Medical University · Theravance Biopharma · US Department of Veterans Affairs · University Health Network, Toronto · University Hospital, Geneva · University Hospital, Tours · University Hospitals Cleveland Medical Center · University at Buffalo · University of Monastir · University of Montreal · University of Utah · Verona Pharma, Inc. · Zhujiang Hospital

Regulatory milestones approvals, filings & regulatory actions · 4 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansions (3) US (FDA) ATROVENT 1998-04-01 – 2000-10-27 fda.gov
Approved US (FDA) ATROVENT 1986-12-29 fda.gov

Trials 64 · started per year

today
US approved 1986
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198419851986198719881989199019911992199319941995199619971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT04617015 Sep 2016 → Mar 2019 childhood onset asthma, depressive disorder State University of New York at Buffalo Completed No outcome recorded
Phase 16 trials
Phase 1 NCT03480997 Dec 2016 → Apr 2017 chronic obstructive pulmonary disease Pneuma Respiratory, Inc Completed No outcome recorded
Phase 1 NCT02872597 Sep 2016 → Aug 2018 status asthmaticus University Hospitals Cleveland Medical Center Completed No outcome recorded
Phase 1 NCT02207452 Aug 2010 → Jul 2011 chronic obstructive pulmonary disease GlaxoSmithKline Completed No outcome recorded
Phase 1 NCT00549120 Aug → Oct 2007 chronic obstructive pulmonary disease GlaxoSmithKline Completed No outcome recorded
Phase 1 NCT02172781 Jan → Apr 2001 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT02173678 Oct → Nov 1999 Boehringer Ingelheim Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT02755714 Jun 2016 → Oct 2020 Haukeland University Hospital Completed No outcome recorded
Phase 212 trials
Phase 2 NCT07394036 Jun 2026 → Dec 2029 expected Cook Children's Health Care System Not yet recruiting No outcome recorded
Phase 2 NCT06074185 Jan 2024 → Feb 2025 childhood onset asthma Oregon Health and Science University Completed No outcome recorded
Phase 2 NCT03747536 Jan → Oct 2019 London Health Sciences Centre Unknown No outcome recorded
Phase 2 NCT02542254 Oct → Dec 2015 chronic obstructive pulmonary disease Verona Pharma, Inc. Completed No outcome recorded
Phase 2 NCT03064113 May → Oct 2011 chronic obstructive pulmonary disease Mylan Inc. Completed No outcome recorded
Phase 2 NCT00818454 Dec 2008 → Sep 2009 asthma Boehringer Ingelheim Completed No outcome recorded
Phase 2 NCT00296946 Nov 2004 → Jun 2006 Parkinson disease University Health Network, Toronto Completed No outcome recorded
Phase 2 NCT00096616 Nov 2004 → Mar 2006 asthma Boehringer Ingelheim Completed No outcome recorded
Phase 2 NCT02260011 Oct 2000 → Feb 2001 chronic obstructive pulmonary disease Boehringer Ingelheim Completed No outcome recorded
Phase 2 NCT02236169 Oct 2000 → Apr 2001 chronic obstructive pulmonary disease Boehringer Ingelheim Completed No outcome recorded
Phase 319 trials
Phase 3 NCT05890638 Aug 2023 → Feb 2024 chronic obstructive pulmonary disease Neutec Ar-Ge San ve Tic A.Ş Unknown No outcome recorded
Phase 3 NCT04446637 Sep 2021 → Sep 2022 chronic obstructive pulmonary disease Neutec Ar-Ge San ve Tic A.Ş Withdrawn No outcome recorded
Phase 3 NCT02782052 Jul 2016 → Oct 2018 pulmonary arterial hypertension Assistance Publique - Hôpitaux de Paris Withdrawn No outcome recorded
Phase 3 NCT01944033 Jul 2013 → Jul 2016 chronic obstructive pulmonary disease University of Monastir Completed No outcome recorded
Phase 3 NCT00462540 May → Sep 2007 chronic obstructive pulmonary disease Dey Completed No outcome recorded
Phase 3 NCT00239434 Jun 2003 → Mar 2004 chronic obstructive pulmonary disease Boehringer Ingelheim Completed No outcome recorded
Phase 3 NCT02176200 Apr 2003 → Dec 2004 chronic obstructive pulmonary disease Boehringer Ingelheim Terminated No outcome recorded
Phase 3 NCT02176187 Apr 2003 → Dec 2004 chronic obstructive pulmonary disease Boehringer Ingelheim Terminated No outcome recorded
Phase 3 NCT02173795 Oct 2002 → Jun 2003 asthma, chronic obstructive pulmonary disease Boehringer Ingelheim Completed No outcome recorded
Phase 3 NCT02177253 Oct 2002 → Mar 2004 chronic obstructive pulmonary disease Boehringer Ingelheim Completed No outcome recorded
Phase 414 trials
Phase 4 NCT06825013 Nov 2024 → Jan 2027 expected chronic obstructive pulmonary disease Dr. J. Alberto Neder Recruiting No outcome recorded
Phase 4 NCT06918418 Jan → Jun 2024 acute asthma Children's Hospital and Institute of Child Health, Multan Completed No outcome recorded
Phase 4 NCT03219866 Oct 2017 → Apr 2020 chronic obstructive pulmonary disease Wake Forest University Health Sciences Terminated No outcome recorded
Phase 4 NCT01943552 Oct 2013 → Jul 2015 chronic obstructive pulmonary disease Boehringer Ingelheim Completed No outcome recorded
Phase 4 NCT02103374 Jan 2012 → Dec 2015 chronic obstructive pulmonary disease University Hospital, Tours Completed No outcome recorded
Phase 4 NCT00388882 Oct 2006 → Oct 2007 chronic obstructive pulmonary disease Boehringer Ingelheim Completed No outcome recorded
Phase 4 NCT00359788 Jul 2006 → Apr 2008 chronic obstructive pulmonary disease Boehringer Ingelheim Completed No outcome recorded
Phase 4 NCT00354354 Mar 2006 → Jul 2009 chronic obstructive pulmonary disease Queen's University Completed No outcome recorded
Phase 4 NCT00202176 Jul 2005 → Dec 2008 chronic obstructive pulmonary disease Queen's University Completed No outcome recorded
Phase 4 NCT02238210 Dec 2002 → May 2003 Boehringer Ingelheim Completed No outcome recorded
Phase not applicable11 trials
NCT05786950 Jan → Jul 2023 chronic obstructive pulmonary disease The First Affiliated Hospital of Guangzhou Medical University Completed No outcome recorded
NCT03071731 Apr 2017 → Jun 2019 chronic obstructive pulmonary disease Laval University Unknown No outcome recorded
NCT03271905 Apr 2017 → Dec 2018 asthma, chronic obstructive pulmonary disease Federal University of Rio Grande do Norte Unknown No outcome recorded
NCT02296047 Dec 2014 → May 2015 chronic obstructive pulmonary disease Zhujiang Hospital Completed No outcome recorded
NCT03062904 Feb 2014 → Dec 2019 Assistance Publique - Hôpitaux de Paris Unknown No outcome recorded
NCT01655199 Sep 2012 → Jul 2014 chronic obstructive pulmonary disease Laval University Unknown No outcome recorded
NCT00381589 Oct 2006 → Jun 2008 Centre for Addiction and Mental Health Completed No outcome recorded
NCT00498251 Sep 2004 → Jun 2007 acute lung injury University Hospital, Geneva Completed No outcome recorded
NCT00583778 Aug 2004 → Nov 2008 asthma MetroHealth Medical Center Completed No outcome recorded
NCT00371527 Oct 2002 → Jan 2004 bronchitis Kaiser Permanente Completed No outcome recorded
Also used as a comparator or background therapy in 37 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/21 trial
Phase 1/2 NCT06657079 Comparator May 2024 → Jan 2025 acute respiratory distress syndrome Damanhour University Completed No outcome recorded
Phase 24 trials
Phase 2 NCT04315558 Comparator Nov 2020 → Jan 2025 acute respiratory failure, chronic obstructive pulmonary disease University of California, Los Angeles Completed No outcome recorded
Phase 2 NCT01426009 Comparator Aug → Dec 2011 chronic obstructive pulmonary disease Sunovion Respiratory Development Inc. Completed No outcome recorded
Phase 2 NCT01350128 Comparator May → Oct 2011 chronic obstructive pulmonary disease Pearl Therapeutics, Inc. Completed No outcome recorded
Phase 2 NCT00117182 Background Jul 2005 → Aug 2006 chronic obstructive pulmonary disease Syntara Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT06376942 Comparator Apr 2024 → Apr 2025 Post Graduate Institute of Medical Education and Research, Chandigarh Unknown No outcome recorded
Phase 37 trials
Phase 3 NCT06040424 Comparator Sep 2023 → Jun 2024 chronic obstructive pulmonary disease Neutec Ar-Ge San ve Tic A.Ş Unknown No outcome recorded
Phase 3 NCT01987219 Comparator Mar 2013 → Dec 2014 Riley-Day syndrome NYU Langone Health Completed No outcome recorded
Phase 3 NCT01019694 Comparator Nov 2009 → Apr 2011 chronic obstructive pulmonary disease Boehringer Ingelheim Completed No outcome recorded
Phase 3 NCT00588406 Background Sep 2007 → Dec 2009 asthma Northwell Health Completed No outcome recorded
Phase 3 NCT01136421 Comparator Jan 2005 → Jun 2007 chronic obstructive pulmonary disease University of Monastir Completed No outcome recorded
Phase 413 trials
Phase 4 NCT04655170 Comparator Dec 2020 → Jan 2023 overdue chronic obstructive pulmonary disease University of Tennessee Graduate School of Medicine Recruiting No outcome recorded
Phase 4 NCT04167280 Comparator Nov 2019 → Mar 2020 asthma University of Saskatchewan Completed No outcome recorded
Phase 4 NCT03738917 Comparator Feb 2019 → Nov 2021 bronchitis Jordi Gol Institute for Primary Care Research Completed No outcome recorded
Phase 4 NCT03405090 Comparator Sep 2017 → Mar 2022 chronic obstructive pulmonary disease Dr. Denis O'Donnell Completed No outcome recorded
Phase 4 NCT02584738 Background Sep 2015 → Jan 2016 asthma Hospital General Naval de Alta Especialidad - Escuela Medico Naval Unknown No outcome recorded
Phase not applicable11 trials
NCT05550402 Comparator Feb → Jun 2024 asthma, obstructive lung disease, parasympathetic nervous system disorder Hat Yai Medical Education Center Unknown No outcome recorded
NCT05183841 Comparator Apr 2022 → Nov 2024 bronchiectasis University of Sao Paulo General Hospital Unknown No outcome recorded
NCT02509299 Background Sep → Nov 2019 chronic obstructive pulmonary disease University of Granada Completed No outcome recorded
NCT03296579 Comparator Jun → Nov 2018 acute asthma, childhood onset asthma University of British Columbia Unknown No outcome recorded
NCT02790047 Background Oct 2016 → Jan 2018 chronic obstructive pulmonary disease Khon Kaen University Unknown No outcome recorded

Evidence & citations 31 cited values

Every value below carries the sentence it was read from. 102 sources stand behind the page.

FieldValueCited text
Known as ipratropium “Group Terbutaline/Ipratropium Bromide received combination of 5 mg Terbutaline (2ml) and 0.5 mg Ipratropium bromide (2ml) and 1ml serum saline in nebulization repeated threeand...” NCT01944033
49

“50 µg Fenoterol Hydrobromide/20 µg Ipratropium Bromide and 25 µg Fenoterol Hydrobromide/10 µg Ipratropium Bromide, 1 Puff q.i.d” NCT02173782

“Test of Bronchodilatation (combined Salbutamol 200μg and Ipratropium bromure 80μg; 2 inhalations): wait 30 min and then” NCT03062904

“Participants will be administered aerosolized budesonide and ipratropium or a placebo every eight hours for five days.” NCT06657079

“50 µg Fenoterol Hydrobromide/20 µg Ipratropium Bromide and 25 µg Fenoterol Hydrobromide/10 µg Ipratropium Bromide” NCT02182479

“comparing the fixed combination of ipratropium and albuterol (IB+ALB) to albuterol alone (ALB).” PMID 18403223 Mar 2008

“All subjects receive inhaled ipratropium once with measurement of spirometry before and after.” NCT04617015

“0.5 mg ipratropium bromide + 2.5 mg salbutamol will be inhaled via nebulizer” NCT03405090

“anticholinergic agents (ipratropium and oxitropium bromide)” NCT02515318

“anticholinergic agents (ipratropium and oxitropium bromide)” NCT02509299

“fenoterol hydrobromide 50μg + ipratropium bromide 20μg” NCT02176187

“of Salbutamol Sulfate, 288 mcg of Ipratropium Bromide” NCT02173678

“Combivent®, ipratropium 0.5 mg + salbutamol 2.5 mg” NCT00354354

NCT00549120

NCT06376942

NCT04446637

NCT03296579

NCT00521222

NCT03064113

NCT06074185

NCT01415518

NCT05183841

NCT00371527

NCT03271905

NCT00274066

NCT01987219

NCT00359788

NCT05786950

NCT02207452

NCT00462540

NCT00904436

NCT04655170

NCT00274040

NCT01691482

NCT02686086

NCT01655199

NCT03480997

NCT00498251

NCT02542254

NCT00000568

NCT02872597

NCT00583778

NCT02182713

NCT00273962

NCT02172781

NCT02458482

NCT01696214

NCT05890638

NCT06040424

NCT04315558

Known as Atrovent “An Open-Label, Crossover, Pharmacokinetic Trial to Determine the Comparability of 84 µg Ipratropium Bromide HFA-134a Inhalation Aerosol to 84 µg ATROVENT® CFC Inhalation...” NCT02236169
13

“To evaluate acute effect of single dose of ipratropium (Atrovent) or fenoterol (Berotec) in comparison to placebo when given to COPD patients on pharmacodynamic steady state of...” NCT00274066

“The objective of this study was to compare the bronchodilator efficacy and safety of ipratropium bromide HFA-134a inhalation aerosol and marketed, Atrovent® CFC Inhalation...” NCT02260011

“Nebulized bronchodilator drugs will be Salbutamol Sulfate (aerolin nebulis) and ipratropium bromide (atrovent) diluted in a saline solution (saline 0.9%) in 3 ml.” NCT03271905

“Bronchodilator Treatment: Subjects will inhale 1 unit dose vial of aerosolized ipratropium (500 mcg of ipratropium (Atrovent) mixed in 2.5 ml of saline).” NCT00904436

“20 mcg and 40 mcg of Ipratropium Bromide, as delivered by the RESPIMAT Device, to 18 mcg ATROVENT® Inhalation Aerosol” NCT02177344

“Ipratropium Bromide (Atrovent) & Albuterol (Ventolin) as Standard of Care” NCT04655170

Atrovent? MDI (2 puffs of ipratropium bromide 20 ?g four times daily)” NCT00239434

“(Atrovent ®)” NCT01987219

NCT03219866

NCT02238210

NCT02103374

NCT02172443

NCT00274092

Known as Atrovent aerocaps ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597
Known as Atrovent fte ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597
Known as Atrovent HFA “Ipratropium bromide (Atrovent® HFA) is a short acting anticholinergic bronchodilator (short acting muscarinic antagonist (SAMA)) that improves lung function, dyspnea, exercise...” NCT00911651
Known as Atrovent udvs ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597
Known as AtroventTM “ipratropium (AtroventTM 20 µg/inhalation, 2 inhalations four times daily)” NCT01415518
Known as Bromure d'ipratropium ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597
Known as Bromuro de ipratropio ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597
Known as Ipratrop ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597
Known as Ipratrop steripoule ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597
Known as ipratropium bromide “Study to demonstrate the comparability of two puffs of Combivent hydrofluoroalkane (HFA) inhalation aerosol (18 mcg ipratropium bromide/100 mcg albuterol sulfate / per puff) to...” NCT02182674
55

“Study to compare the lung and oropharyngeal deposition of Berodual® (fenoterol hydrobromide 50μg + ipratropium bromide 20μg /1x puff) delivered via the Respimat® inhaler and...” NCT02176200

“This study's objective was to evaluate whether ipratropium bromide/albuterol metered-dose inhaler (CVT-MDI) provides more effective acute relief of bronchospasm in...” PMID 27130202 Apr 2016

“Nebulized bronchodilator drugs will be Salbutamol Sulfate (aerolin nebulis) and ipratropium bromide (atrovent) diluted in a saline solution (saline 0.9%) in 3 ml.” NCT03271905

“the simultaneous administration of ipratropium bromide hydrofluoroalkane (HFA; I) and albuterol HFA (A) metered-dose inhalers as dual monotherapies (I + A).” PMID 23658479 Mar 2013

“The bronchodilator consisted of ipratropium bromide prescribed three times daily, two puffs per time, from a metered-dose inhaler.” NCT00000568

“inhaled compound ipratropium bromide solution (3mg salbutamol and 500μg ipratropium, Boehringer Ingelheim Limited, Germany)” NCT05786950

“Nebulization of ipratropium bromide/salbutamol sulfate (500 µg/2.5 mg) before the administration of the Glittre ADL-test” NCT03071731

“Berodual® Respimat® (20 µg ipratropium bromide + 50 µg fenoterol hydrobromide per actuation for 49 days)” NCT02173795

“0.5 mg ipratropium bromide + 2.5 mg salbutamol will be inhaled via nebulizer” NCT03405090

Ipratropium Bromide (Atrovent) & Albuterol (Ventolin) as Standard of Care” NCT04655170

“Salbutamol sulfate 120 mcg + Ipratropium bromide 20 mcg per puff” NCT02182713

“Salbutamol sulphate (2.5 mg) + ipratropium bromide (0.5 mg)” NCT06825013

Ipratropium bromide 18 mcg and albuterol sulfate 103 mcg” NCT00462540

“50 µg Fenoterol Hydrobromide + 20 µg Ipratropium BromideNCT02182505

“MDI to deliver 20mcg per puff ipratropium bromideNCT04167280

“Ipratropium-bromide (Atrovent ®)” NCT01987219

Ipratropium bromide (inhaler)” NCT02790047

NCT02755714

NCT06657079

NCT00180843

NCT00807534

NCT02260011

NCT03738917

NCT02235428

NCT00296946

NCT01426009

NCT01136421

NCT00393367

NCT01350128

NCT00202176

NCT01943552

NCT04617015

NCT00588406

NCT02584738

NCT00911651

NCT05550402

NCT01691079

NCT00117182

NCT02182856

NCT02236169

NCT02182700

NCT02236182

NCT07394036

NCT02177253

NCT00239434

NCT02172469

NCT00388882

NCT02296047

NCT02177344

NCT02782052

NCT03747536

NCT00381589

NCT00460577

NCT00605410

NCT06918418

Known as Ipratropium bromide anhydrous ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597
Known as Ipratropium bromide component of combivent ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597
Known as Ipratropium bromide component of duoneb ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597
Known as Ipratropium bromide component of duovent ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597
Known as Ipratropium bromide hydrate ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597
Known as Ipratropium bromide monohydrate ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597
Known as Ipratropium cation ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597
Known as Ipratropium ion ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597
Known as NSC-759613 ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597
Known as Respontin ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597
Known as Rinatec ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597
Known as SCH 1000-BR-MONOHYDRATE ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597
Known as SCH-1000-BR- ChEMBL registry synonym — accepted as the source's own label CHEMBL1621597