Atrovent in Exercise Induced Laryngeal Obstruction (EILO)

Summary

Exercise Induced Laryngeal Obstruction (EILO) is a condition not uncommon in otherwise healthy young people. EILO is caused by posteromedial collapse of supraglottic structures or medialization of the vocal folds, or both, during high intensity exercise. There are currently no treatments available that is properly evidence based. However, case reports suggest a possible effect from the "asthma drug" Ipratropium Bromide (Atrovent®). The current project is an open label pilot study, aiming to test if Atrovent can influence the occurence of EILO, either postponing the onset during exercise or fully prevent the condition to occur.

Timeline

Start

2016-06-22

Primary completion

2020-10-31

Completion

2020-10-31

Publications

• Background Roksund OD, Heimdal JH, Olofsson J, Maat RC, Halvorsen T. Larynx during exercise: the unexplored bottleneck of the airways. Eur Arch Otorhinolaryngol. 2015 Sep;272(9):2101-9. doi: 10.1007/s00405-014-3159-3. Epub 2014 Jul 18.
• Background Christopher KL, Wood RP 2nd, Eckert RC, Blager FB, Raney RA, Souhrada JF. Vocal-cord dysfunction presenting as asthma. N Engl J Med. 1983 Jun 30;308(26):1566-70. doi: 10.1056/NEJM198306303082605.
• Background Maat RC, Hilland M, Roksund OD, Halvorsen T, Olofsson J, Aarstad HJ, Heimdal JH. Exercise-induced laryngeal obstruction: natural history and effect of surgical treatment. Eur Arch Otorhinolaryngol. 2011 Oct;268(10):1485-92. doi: 10.1007/s00405-011-1656-1. Epub 2011 Jun 5.
• Background Johansson H, Norlander K, Berglund L, Janson C, Malinovschi A, Nordvall L, Nordang L, Emtner M. Prevalence of exercise-induced bronchoconstriction and exercise-induced laryngeal obstruction in a general adolescent population. Thorax. 2015 Jan;70(1):57-63. doi: 10.1136/thoraxjnl-2014-205738. Epub 2014 Nov 7.
• Background Hull JH, Selby J, Sandhu G. "You say potato, I say potato": time for consensus in exercise-induced laryngeal obstruction? Otolaryngol Head Neck Surg. 2014 Nov;151(5):891-2. doi: 10.1177/0194599814549529. No abstract available.
• Results Muralitharan P, Carlsen P, Hilland M, Delestre-Levai I, Vollsaeter M, Hufthammer KO, Engan M, Roksund OD, Halvorsen T, Clemm HH. Use of inhaled ipratropium bromide to improve exercise-induced laryngeal obstruction cannot be recommended. ERJ Open Res. 2023 Jan 23;9(1):00308-2022. doi: 10.1183/23120541.00308-2022. eCollection 2023 Jan.

Drugs

Indications

No indication recorded.