A Comparative Study of Adding Ipratropium to Salbutamol for the Treatment of Asthma Attack in Children

Summary

The goal of this clinical trial was to determine if adding ipratropium bromide to salbutamol improves asthma treatment in children. The main question this study aimed to answer was: Does combining ipratropium with salbutamol improve asthma symptoms more effectively than salbutamol alone? Researchers compared salbutamol alone to a combination of salbutamol and ipratropium in children with acute asthma. Participants: (i) Received either salbutamol alone or salbutamol with ipratropium via nebulization for 4 hours (ii) Had their asthma symptoms assessed before and after treatment (iii) Were discharged with continued treatment and counseling if stable This study was conducted in the Department of Pediatric Medicine, Children's Hospital Multan, over six months. A total of 60 children with acute asthma were included.

Timeline

Start

2024-01-01

Primary completion

2024-06-30

Completion

2024-07-15

Publications

• Background Iramain R, Lopez-Herce J, Coronel J, Spitters C, Guggiari J, Bogado N. Inhaled salbutamol plus ipratropium in moderate and severe asthma crises in children. J Asthma. 2011 Apr;48(3):298-303. doi: 10.3109/02770903.2011.555037. Epub 2011 Feb 21.
• Background Memon BN, Parkash A, Ahmed Khan KM, Gowa MA, Bai C. Response to nebulized salbutamol versus combination with ipratropium bromide in children with acute severe asthma. J Pak Med Assoc. 2016 Mar;66(3):243-6.

Drugs

Indications