drugset / Trial / NCT01136421

Magnesium Sulfate Versus Ipratropuim Bromide in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

NCT01136421

Phase 3 Completed 124 enrolled University of Monastir
RandomizedParallel-groupQuadruple-blindTreatment

Summary

Treatment with short acting β2 agonists for exacerbations of COPD results in clinical improvement. It has not been established whether combining short acting β2 agonists to other bronchodilators is more effective than β2 agonists alone. The aim of this study is to evaluate the efficacy and safety of combination of SABA and MgSO4 in comparison to SABA and ipratropium bromide (IB) in patients attending the emergency department for AECOPD.

Timeline

Start
2005-01
Primary completion
2007-06
Completion
2007-06

Drugs

EvaluationDrugModalityDoseRoute
Comparator Ipratropium Small molecule 0.5 mg Inhaled
Subject Magnesium Sulfate Other / unclassified 150 mg Inhaled
Subject Magnesium Sulfate Other / unclassified 1.5 g Inhaled