Comparison of Side Effects of Morphine and Hydromorphone Patient-Controlled Analgesia (PCA)

Phase 4 Completed 50 enrolled Columbia University

RandomizedParallel-groupQuadruple-blindTreatment

Summary

Both morphine and hydromorphone are pain medications commonly used after surgery. It is thought at the institution that hydromorphone causes less side effects but this has not been studied. The study proposes to treat the patients with either morphine or hydromorphone and determine how much nausea, vomiting, and itching they have with each drug

Timeline

Start: 2003-11
Primary completion: 2007-10
Completion: 2007-10

Publications

Results Hong D, Flood P, Diaz G. The side effects of morphine and hydromorphone patient-controlled analgesia. Anesth Analg. 2008 Oct;107(4):1384-9. doi: 10.1213/ane.0b013e3181823efb.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Hydromorphone	Other / unclassified	0.2 mg	—
Comparator	Morphine	Other / unclassified	1 mg	—

Indications

No indication recorded.