drugset / Trial / NCT00386958
A Clinical Trial of Povidone-Iodine for the Treatment of Bacterial Corneal Ulcers
Phase 2
Completed
172 enrolled
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Joseph Eye Hospital · collabKolokotrones Family Foundation · collabL.V. Prasad Eye Institute · collabResearch to Prevent Blindness · collabThrasher Research Fund · collabUniversity of California, Los Angeles · collabUniversity of the Philippines · collab
RandomizedParallel-groupDouble-blindTreatment
Summary
Bacterial corneal ulcers are a leading cause of pediatric blindness in underdeveloped countries due to a lack of antibiotic availability and affordability, among other reasons. Povidone-iodine, an inexpensive and readily available broad-spectrum antimicrobial agent, may be an effective and affordable treatment for corneal ulcers, allowing preservation of sight for those afflicted with this disease.
Timeline
- Start
- 2002-11
- Primary completion
- 2006-01
- Completion
- 2006-01
Publications
- Background Isenberg SJ, Apt L, Yoshimori R, Pham C, Lam NK. Efficacy of topical povidone-iodine during the first week after ophthalmic surgery. Am J Ophthalmol. 1997 Jul;124(1):31-5. doi: 10.1016/s0002-9394(14)71640-x.
- Background Berkelman RL, Holland BW, Anderson RL. Increased bactericidal activity of dilute preparations of povidone-iodine solutions. J Clin Microbiol. 1982 Apr;15(4):635-9. doi: 10.1128/jcm.15.4.635-639.1982.
- Background Benevento WJ, Murray P, Reed CA, Pepose JS. The sensitivity of Neisseria gonorrhoeae, Chlamydia trachomatis, and herpes simplex type II to disinfection with povidone-iodine. Am J Ophthalmol. 1990 Mar 15;109(3):329-33. doi: 10.1016/s0002-9394(14)74560-x.
- Background Holderman LV, Cato EP, Moore WEC. Anaerobe Laboratory Manual. Blacksburg, Virginia. VPI Anaerobic Laboratory, 1977
- Background Everett SL, Kowalski RP, Karenchak LM, Landsittel D, Day R, Gordon YJ. An in vitro comparison of the susceptibilities of bacterial isolates from patients with conjunctivitis and blepharitis to newer and established topical antibiotics. Cornea. 1995 Jul;14(4):382-7. doi: 10.1097/00003226-199507000-00006.
- Background HOGAN MJ, KIMURA SJ, THYGESON P. Signs and symptoms of uveitis. I. Anterior uveitis. Am J Ophthalmol. 1959 May;47(5 Pt 2):155-70. doi: 10.1016/s0002-9394(14)78239-x. No abstract available.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Povidone-Iodine | Other / unclassified | 1.25 % | Topical |