drugset / Trial / NCT00392275
Penetrance of Third Generation Fluoroquinolones in Eyes With Functioning Filtering Blebs
RandomizedParallel-groupSingle-blindTreatment
Summary
Based on previous results with eyes without filtering blebs, the aqueous concentrations of ofloxacin and levofloxacin will exceed the concentration of ciprofloxacin after either topical or topical plus oral administration.
Timeline
- Start
- 2002-11
- Primary completion
- —
- Completion
- 2006-05
Publications
- Background Cantor LB, Donnenfeld E, Katz LJ, Gee WL, Finley CD, Lakhani VK, Hoop J, Flarty K. Penetration of ofloxacin and ciprofloxacin into the aqueous humor of eyes with functioning filtering blebs: a randomized trial. Arch Ophthalmol. 2001 Sep;119(9):1254-7. doi: 10.1001/archopht.119.9.1254.
- Cantor LB, WuDunn D, Yung CW, Valluri S, Catoira YP, Hoop JS, Morgan LS. Ocular penetration of levofloxacin, ofloxacin and ciprofloxacin in eyes with functioning filtering blebs: investigator masked, randomised clinical trial. Br J Ophthalmol. 2008 Mar;92(3):345-7. doi: 10.1136/bjo.2007.121541. Epub 2008 Jan 22.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Ciprofloxacin | Small molecule | 0.3 % | Topical |
| Subject | Ciprofloxacin | Small molecule | 400 mg | Topical |
| Subject | Levofloxacin | Small molecule | 0.5 % | Topical |
| Subject | Levofloxacin | Small molecule | 250 mg | Topical |
| Subject | Ofloxacin | Small molecule | 0.3 % | Topical |
| Subject | Ofloxacin | Small molecule | 400 mg | Topical |