Treatment of Head & Neck Cancer With Chemotherapy and Radiation

Phase 2 Completed 60 enrolled SCRI Development Innovations, LLC Genentech, Inc. · collab

NaSingle-groupOpen-labelTreatment

Summary

Two new cancer treatment drugs called targeted therapies will be added to standard treatment for head and neck cancer to see if an improvement can be made in the effectiveness of treatment for this type of cancer. Treatment will include chemotherapy, radiation therapy and targeted therapy taken over a period of 4 months.

Timeline

Start: 2006-12
Primary completion: 2008-08
Completion: 2012-05

Publications

Background Hainsworth JD, Spigel DR, Greco FA, Shipley DL, Peyton J, Rubin M, Stipanov M, Meluch A. Combined modality treatment with chemotherapy, radiation therapy, bevacizumab, and erlotinib in patients with locally advanced squamous carcinoma of the head and neck: a phase II trial of the Sarah Cannon oncology research consortium. Cancer J. 2011 Sep-Oct;17(5):267-72. doi: 10.1097/PPO.0b013e3182329791.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Bevacizumab	Monoclonal antibody	15 mg/kg	Intravenous
Subject	Erlotinib	Small molecule	150 mg	Oral
Subject	Paclitaxel	Small molecule	50 mg/m2	Intravenous
Subject	fluorouracil	Small molecule	200 mg/m2	Intravenous

Treatment of Head & Neck Cancer With Chemotherapy and Radiation

Summary

Timeline

Publications

Drugs

Indications