drugset / Trial / NCT00398229

hCG Supplementation in Frozen-Thawed Embryo Transfer Cycle

NCT00398229

Phase 2 Completed 300 enrolled Hadassah Medical Organization
RandomizedParallel-groupOpen-labelTreatment

Summary

The implantation rate after frozen-thawed embryo transfer cycles depends mostly on the receptivity of the endometrium and the embryo quality.The effects of human chorionic gonadotropins (hCG) on the endometrium have been investigated for several years. hCG was shown to up-regulate gene expression during the differentiation of human endometrial stromal cells into decidua. The aim of our study was to assess the benefit of hCG supplementation throughout the secretory phase of artificial frozen-thawed embryo transfer cycles.

Timeline

Start
2006-11
Primary completion
Completion
2008-05

Drugs

EvaluationDrugModalityDoseRoute
Comparator human chorionic gonadotropin Protein / enzyme biologic 250 ug Subcutaneous

Indications