PDE5-Inhibition With Sildenafil in Chronic Heart Failure

Summary

To test the hypothesis that long-term PDE5-inhibition by overexpressing the nitric oxide pathway is beneficial in chronic heart failure patients. Double-blind and placebo-controlled trial. Primary end-points: quality of life and exercise performance

Timeline

Start

2004-01

Primary completion

—

Completion

2005-02

Publications

• Background Katz SD, Parker JD, Glasser DB, Bank AJ, Sherman N, Wang H, Sweeney M. Efficacy and safety of sildenafil citrate in men with erectile dysfunction and chronic heart failure. Am J Cardiol. 2005 Jan 1;95(1):36-42. doi: 10.1016/j.amjcard.2004.08.060.

Drugs

Indications