drugset / Trial / NCT00411190

Study To Determine The Effects Of Doses Of Relacatib On The Metabolism Of Acetaminophen, Ibuprofen And Atorvastatin

NCT00411190

Phase 1 Completed 32 enrolled GlaxoSmithKline
RandomizedParallel-groupOpen-labelDiagnostic

Summary

Relacatib is being developed for the treatment of osteoporosis, osteoarthritis and possibly other bone disorders. Recent results suggest that relacatib interacts with the way our bodies metabolise drugs and so some drugs which are commonly prescribed to the intended target patient population could be affected by giving relacatib at the same time. The purpose of this study is to evaluate the effect of repeat dose administration of relacatib on the way subjects bodies metabolise three commonly prescribed medications in the osteoarthritis population: ibuprofen, acetaminophen, and atorvastatin.

Timeline

Start
2006-10-19
Primary completion
2006-12-15
Completion
2006-12-15

Drugs

EvaluationDrugModalityDoseRoute
Subject Acetaminophen Small molecule 500 mg Oral
Subject Atorvastatin Small molecule 40 mg Oral
Subject Ibuprofen Small molecule 400 mg Oral
Subject Relacatib Small molecule 60 mg
Subject Relacatib Small molecule 120 mg

Indications