Viral Kinetics Study of Telbivudine and Entecavir in Adults With Chronic Hepatitis B

Phase 3 Completed 44 enrolled Novartis Pharmaceuticals

RandomizedParallel-groupOpen-labelTreatment

Summary

This exploratory study is designed to determine the early viral kinetic profile during treatment with telbivudine or entecavir at multiple time points over 12 weeks.

Timeline

Start: 2006-12
Primary completion: 2008-02
Completion: —

Publications

Results Suh DJ, Um SH, Herrmann E, Kim JH, Lee YS, Lee HJ, Lee MS, Lee YJ, Bao W, Lopez P, Lee HC, Avila C, Zeuzem S. Early viral kinetics of telbivudine and entecavir: results of a 12-week randomized exploratory study with patients with HBeAg-positive chronic hepatitis B. Antimicrob Agents Chemother. 2010 Mar;54(3):1242-7. doi: 10.1128/AAC.01163-09. Epub 2009 Dec 22.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Entecavir	Small molecule	0.5 mg	Oral
Subject	Telbivudine	Small molecule	600 mg	Oral

Viral Kinetics Study of Telbivudine and Entecavir in Adults With Chronic Hepatitis B

Summary

Timeline

Publications

Drugs

Indications