drugset / Trial / NCT00425477

Bexarotene and GM-CSF in Treating Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia

NCT00425477

NaSingle-groupOpen-labelTreatment

Summary

RATIONALE: Bexarotene may help cancer or abnormal cells become more like normal cells, and to grow and spread more slowly. Colony-stimulating factors, such as GM-CSF, may increase the number of immune cells found in bone marrow or peripheral blood. Giving bexarotene together with GM-CSF may be an effective treatment for myelodysplastic syndrome (MDS) or acute myeloid leukemia. PURPOSE: This phase II trial is studying how well giving bexarotene together with GM-CSF works in treating patients with MDS or acute myeloid leukemia.

Timeline

Start
2006-11
Primary completion
2016-09-30
Completion
2016-09-30

Drugs

EvaluationDrugModalityDoseRoute
Subject Bexarotene Small molecule 300 mg/m2 Oral
Subject sargramostim Protein / enzyme biologic 125 ug/m2 Subcutaneous