A RCT of Ondansetron and Promethazine in the Treatment of Nausea and Vomiting in the Emergency Department

Phase 4 Completed 120 enrolled University of New Mexico GlaxoSmithKline · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

This was a trial comparing two commonly used medications for nausea and vomiting, ondansetron and promethazine, in the Emergency Department.

Timeline

Start: 2003-10
Primary completion: —
Completion: 2005-11

Outcome

Met primary endpoint

paper Ondansetron and promethazine reduced nausea similarly (ondansetron -34 mm, promethazine -36 mm; difference -2 mm; 95% CI = -13 to 8 mm). PMID 18304050 ↗

Publications

Braude D, Crandall C. Ondansetron versus promethazine to treat acute undifferentiated nausea in the emergency department: a randomized, double-blind, noninferiority trial. Acad Emerg Med. 2008 Mar;15(3):209-15. doi: 10.1111/j.1553-2712.2008.00060.x.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ondansetron	Other / unclassified	4 mg	Intravenous
Subject	Promethazine	Small molecule	25 mg	Intravenous

Indications

No indication recorded.