Effectiveness of Tropisetron Plus Risperidone for Improving Cognitive and Perceptual Disturbances in Schizophrenia

Summary

This study will determine the effectiveness of tropisetron plus risperidone in improving cognitive symptoms in Chinese people with schizophrenia.

Timeline

Start

2006-11

Primary completion

2011-02

Completion

2011-08

Outcome

Met primary endpoint

registry analysis (superiority or other test); Tropisetron vs Placebo; p <0.05; ANCOVA NCT00435370 ↗

Publications

• Yang M, Liu L, Cui H, Deng C, Xiong W, Zhao G, Du S, Kosten TR, Chen H, Li Z, Zhang X. Dynamic functional thalamocortical dysconnectivity in schizophrenia correlates to antipsychotics response. Schizophrenia (Heidelb). 2023 Jul 4;9(1):40. doi: 10.1038/s41537-023-00371-y.
• Zhang XY, Liu L, Liu S, Hong X, Chen DC, Xiu MH, Yang FD, Zhang Z, Zhang X, Kosten TA, Kosten TR. Short-term tropisetron treatment and cognitive and P50 auditory gating deficits in schizophrenia. Am J Psychiatry. 2012 Sep;169(9):974-81. doi: 10.1176/appi.ajp.2012.11081289.

Drugs

Indications