Drugs / Tropisetron
Tropisetron
also known as
ICS-205-930 · Navoban · Novaban · NSC-759842 · SDZ-ICS-930 · Tropisetron (as hydrochloride) · Tropisetron hcl · Tropisetron hydrochloride · +1 more
Trials 8 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 31 trial | ||||||
| Phase 3 | NCT00435370 | Nov 2006 → Feb 2011 | schizophrenia | Baylor College of Medicine | Completed | No outcome recorded |
| Phase 45 trials | ||||||
| Phase 4 | NCT05533281 | Sep 2022 → Oct 2023 | — | The Second Affiliated Hospital of Chongqing Medical University | Completed | No outcome recorded |
| Phase 4 | NCT04195204 | Nov 2020 → Dec 2022 | delirium, subjective cognitive decline | Beijing Chao Yang Hospital | Unknown | No outcome recorded |
| Phase 4 | NCT04027751 | Aug 2019 → Dec 2021 | delirium | Beijing Chao Yang Hospital | Unknown | No outcome recorded |
| Phase 4 | NCT01304953 | Jan → Nov 2010 | neuropathy, painful | Huazhong University of Science and Technology | Completed | No outcome recorded |
| Phase 4 | NCT00487110 | Jun → Dec 2008 | — | University Hospital, Clermont-Ferrand | Completed | No outcome recorded |
| Phase not applicable2 trials | ||||||
| — | NCT01843868 | Jan 2012 → Jun 2015 | non-Hodgkin lymphoma | Australasian Leukaemia and Lymphoma Group | Withdrawn | No outcome recorded |
| — | NCT00970450 | Nov 2009 → Mar 2010 | — | University Hospital, Basel, Switzerland | Completed | No outcome recorded |
Also used as a comparator or background therapy in 18 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 23 trials | ||||||
| Phase 2 | NCT01895010 Comparator | Jun 2013 → Dec 2014 | liver cancer | Fudan University | Unknown | No outcome recorded |
| Phase 2 | NCT00889499 Comparator | Mar 2009 → Apr 2010 | — | Insel Gruppe AG, University Hospital Bern | Completed | No outcome recorded |
| Phase 2 | NCT00003817 Background | Oct 1999 → Jul 2001 | cancer of unknown primary site | Gary Morrow | Completed | No outcome recorded |
| Phase 34 trials | ||||||
| Phase 3 | NCT07413809 Background | Oct 2025 → Sep 2027 expected | plasma cell myeloma | The Affiliated People's Hospital of Ningbo University | Recruiting | No outcome recorded |
| Phase 3 | NCT05242874 Background | Feb 2022 → Aug 2023 | chemotherapy-induced toxicity | Henan Cancer Hospital | Completed | No outcome recorded |
| Phase 3 | NCT05564286 Background | Jul 2021 → Jul 2023 | cervical cancer, chemotherapy-induced toxicity, nasopharyngeal carcinoma | Shantou University Medical College | Completed | No outcome recorded |
| Phase 3 | NCT02909478 Comparator | Sep 2017 → Oct 2019 | chemotherapy-induced toxicity, colorectal cancer | Sun Yat-sen University | Completed | No outcome recorded |
| Phase 45 trials | ||||||
| Phase 4 | NCT05331651 Background | Apr 2022 → Jun 2023 | — | The Second Affiliated Hospital of Chongqing Medical University | Completed | No outcome recorded |
| Phase 4 | NCT04817189 Comparator | Feb 2021 → Jul 2024 | chemotherapy-induced toxicity | Helsinn Healthcare SA | Completed | No outcome recorded |
| Phase 4 | NCT03571126 Background | May 2019 → Oct 2022 | chemotherapy-induced toxicity, lung cancer | Zunyi Medical College | Unknown | No outcome recorded |
| Phase 4 | NCT02576327 Background | Oct 2015 → Oct 2017 | — | Jun Zhu | Unknown | No outcome recorded |
| Phase 4 | NCT01636947 Background | Dec 2012 → Aug 2014 | — | Merck Sharp & Dohme LLC | Completed | No outcome recorded |
| Phase not applicable6 trials | ||||||
| — | NCT06668298 Background | Nov 2024 → Jun 2025 overdue | — | Henan Provincial People's Hospital | Not yet recruiting | No outcome recorded |
| — | NCT02625181 Background | Jul 2016 → Nov 2017 | — | Vanderbilt University | Completed | No outcome recorded |
| — | NCT02478047 Comparator | Jun 2015 → Jun 2016 | chemotherapy-induced toxicity | Tianjin University of Traditional Chinese Medicine | Unknown | No outcome recorded |
| — | NCT02195921 Comparator | Apr 2015 → Mar 2016 | chemotherapy-induced toxicity | Tianjin University of Traditional Chinese Medicine | Completed | No outcome recorded |
| — | NCT02195908 Comparator | Aug 2014 → Jul 2015 | — | Tianjin University of Traditional Chinese Medicine | Completed | No outcome recorded |
| — | NCT02096835 Comparator | Jan → Dec 2014 | — | Huashan Hospital | Completed | No outcome recorded |
Evidence & citations 13 cited values
Every value below carries the sentence it was read from. 28 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Tropisetron | “5HT3 (5-Hydroxytryptamine 3) antagonists (ondansetron, granisetron or tropisetron) used as the local institutional standard of care will be permitted, although the preferential...” NCT01843868 ↗25“5-hydroxytryptamine-3 (5-HT3) antagonist (Ramosetron, Tropisetron) and dexamethasone are supplied from the first day of chemotherapy, and lasting for 3-5 days.” NCT02195908 ↗ “5-hydroxytryptamine-3 (5-HT3) antagonist (Ramosetron , Tropisetron)and dexamethasone are supplied from the first day of chemtherapy,and lasting for 3-5days.” NCT02195921 ↗ “The formula for postoperative analgesia pump is oliceridine 0.4mg · kg-1+tropisetron 10mg, mixed with physiological saline to 100ml.” NCT06668298 ↗ “Dexamethasone (10mg/d) (Days1-3) Tropisetron (4mg or 4.48mg or 5mg /d) (Days1-3) Olanzapine (10mg/d) (Days1-4)” NCT03571126 ↗ “Patients in this arms received tropisetron 2 mg i.v. after the induction of anaesthesia.” NCT01304953 ↗ |
| Known as | ICS-205-930 | ChEMBL registry synonym — accepted as the source's own label CHEMBL56564 ↗ |
| Known as | Navoban | ChEMBL registry synonym — accepted as the source's own label CHEMBL56564 ↗ |
| Known as | Novaban | ChEMBL registry synonym — accepted as the source's own label CHEMBL56564 ↗ |
| Known as | NSC-759842 | ChEMBL registry synonym — accepted as the source's own label CHEMBL56564 ↗ |
| Known as | SDZ-ICS-930 | ChEMBL registry synonym — accepted as the source's own label CHEMBL56564 ↗ |
| Known as | Tropisetron (as hydrochloride) | ChEMBL registry synonym — accepted as the source's own label CHEMBL56564 ↗ |
| Known as | Tropisetron hcl | ChEMBL registry synonym — accepted as the source's own label CHEMBL56564 ↗ |
| Known as | Tropisetron hydrochloride | ChEMBL registry synonym — accepted as the source's own label CHEMBL56564 ↗ |
| Known as | Tropisetron monohydrochloride | ChEMBL registry synonym — accepted as the source's own label CHEMBL56564 ↗ |
| Action | Activate | “tropisetron, a partial agonist at the nAChR” PMID 22952075 ↗ Sep 2012 |
| Modality | Small molecule | — CHEMBL56564 ↗ |
| Route | Oral | “or oral tropisetron at 5 mg/day” PMID 22952075 ↗ Sep 2012 |