Effect of Glycopyrronium in Combination With Tropisetron in Anti-postoperative Nausea and Vomiting

RandomizedParallel-groupTriple-blindTreatment

Summary

To compare the anti-nausea and vomiting effect between glycopyrronium in combination with tropisetron and normal saline in combination with tropisetron for patients receiving elective surgery under general anesthesia. Based on this study the investigators intend to explore the feasibility of using glycopyrronium as adjuvant drug to prevent postoperative nausea and vomiting.

Timeline

Start: 2022-04-21
Primary completion: 2023-06-30
Completion: 2023-06-30

Publications

Chen J, Piao G, Luan G, Yu Y, Zheng W, Li Y, Zhang C, Duan Y, Zhao M, Zhang Y, Xiang W, Cheng L, Ji C, Duan G, Huang H. Effects of Glycopyrronium Bromide as an Adjuvant Treatment in the Prevention of Nausea and Vomiting After Abdominal, Thyroid, and Breast Surgery: A Multicenter Randomized Controlled Trial. Drug Des Devel Ther. 2025 Aug 19;19:7123-7134. doi: 10.2147/DDDT.S515670. eCollection 2025.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Glycopyrronium	Unknown	0.2 mg	Intravenous
Background	Tropisetron	Small molecule	4 mg	Intravenous

Indications

No indication recorded.