Fluoride Varnish in the Prevention of Dental Caries in Aboriginal and Non-aboriginal Children

Phase 3 Unknown 1320 enrolled University of Toronto Canadian Institutes of Health Research (CIHR) · collab The Hospital for Sick Children · collab

RandomizedParallel-groupSingle-blindPrevention

Summary

The purpose of this study is to determine whether semi-annual fluoride varnish applications combined with caregiver counseling are effective in preventing and reducing a severe form of dental decay, known as early childhood caries, in native and non-native children aged 6 months to 5 years.

Timeline

Start: 2003-06
Primary completion: —
Completion: 2006-01

Outcome

Met primary endpoint

paper Adjusted odds ratio for caries incidence was 1.96 times higher in the controls than in the FV group (95% CI = 1.08-3.56; P = 0.027). PMID 18422711 ↗

Publications

Lawrence HP, Binguis D, Douglas J, McKeown L, Switzer B, Figueiredo R, Laporte A. A 2-year community-randomized controlled trial of fluoride varnish to prevent early childhood caries in Aboriginal children. Community Dent Oral Epidemiol. 2008 Dec;36(6):503-16. doi: 10.1111/j.1600-0528.2008.00427.x. Epub 2008 Apr 14.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	sodium fluoride	Unknown	5 %	Topical