Effectiveness of Botulinum Toxin Injection in the Tennis Elbow Treatment

Summary

Some studies valued the effectiveness of botulinum toxin. Results are contradictory and we need more studies. The purpose of the study is to compare the effectiveness of botulinum toxin injection with placebo in the treatment of tennis elbow unrelieved by usual medical care performed during 6 months. Method : It is a double blind randomized controlled trial. Principal criteria of assessment is Pain intensity three months after injection.

Timeline

Start

2007-04

Primary completion

2012-06

Completion

2012-06

Outcome

Met primary endpoint

paper reported a >50% reduction in initial pain intensity at day 90 (p = 0.005). PMID 29762276 ↗

Publications

• Results Cogne M, Petit H, Creuze A, Liguoro D, de Seze M. Are paraspinous intramuscular injections of botulinum toxin a (BoNT-A) efficient in the treatment of chronic low-back pain? A randomised, double-blinded crossover trial. BMC Musculoskelet Disord. 2017 Nov 15;18(1):454. doi: 10.1186/s12891-017-1816-6.
• Results Creuze A, Petit H, de Seze M. Short-Term Effect of Low-Dose, Electromyography-Guided Botulinum Toxin A Injection in the Treatment of Chronic Lateral Epicondylar Tendinopathy: A Randomized, Double-Blinded Study. J Bone Joint Surg Am. 2018 May 16;100(10):818-826. doi: 10.2106/JBJS.17.00777.

Drugs

Indications