drugset / Trial / NCT00448266
Intensified IAA With PBPC Support in Breast Tumors With Evidence of a HRD
RandomizedParallel-groupOpen-labelTreatment
Summary
This phase II/III trial will investigate the ability of chemotherapy with 'Intensified Aklylating Agents (IAA) to achieve a high pathological complete response (pCR) rate when employed in the preoperative chemotherapy of breast cancer with evidence of a Homologous Recomination Deficiency (HRD).
Timeline
- Start
- 2007-05
- Primary completion
- 2010-02
- Completion
- 2011-02
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Carboplatin | Small molecule | 800 g | — |
| Subject | Cyclophosphamide | Other / unclassified | 3 g | — |
| Comparator | Doxorubicin | Other / unclassified | — | — |
| Subject | Thiotepa | Other / unclassified | 240 g | — |