drugset / Trial / NCT00448266

Intensified IAA With PBPC Support in Breast Tumors With Evidence of a HRD

NCT00448266

Phase 2/3 Terminated 12 enrolled The Netherlands Cancer Institute
RandomizedParallel-groupOpen-labelTreatment

Summary

This phase II/III trial will investigate the ability of chemotherapy with 'Intensified Aklylating Agents (IAA) to achieve a high pathological complete response (pCR) rate when employed in the preoperative chemotherapy of breast cancer with evidence of a Homologous Recomination Deficiency (HRD).

Timeline

Start
2007-05
Primary completion
2010-02
Completion
2011-02

Drugs

EvaluationDrugModalityDoseRoute
Subject Carboplatin Small molecule 800 g
Subject Cyclophosphamide Other / unclassified 3 g
Comparator Doxorubicin Other / unclassified
Subject Thiotepa Other / unclassified 240 g

Indications