drugset / Trial / NCT00460499
Improving Outcomes In Diabetic Patients During CABG Surgery By Optimizing Glycemic Control
RandomizedFactorialSingle-blindTreatment
Summary
This study seeks to determine whether varying the dose of insulin and glucose in diabetic patients during coronary bypass surgery will improve outcomes in these patients.
Timeline
- Start
- 2004-07
- Primary completion
- 2015-03
- Completion
- 2015-03
Publications
- Bellon F, Sola I, Gimenez-Perez G, Hernandez M, Metzendorf MI, Rubinat E, Mauricio D. Perioperative glycaemic control for people with diabetes undergoing surgery. Cochrane Database Syst Rev. 2023 Aug 1;8(8):CD007315. doi: 10.1002/14651858.CD007315.pub3.
- Lazar HL, McDonnell MM, Chipkin S, Fitzgerald C, Bliss C, Cabral H. Effects of aggressive versus moderate glycemic control on clinical outcomes in diabetic coronary artery bypass graft patients. Ann Surg. 2011 Sep;254(3):458-63; discussion 463-4. doi: 10.1097/SLA.0b013e31822c5d78.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | 20% D-glucose (aq) | Unknown | 20 % | Intravenous |
| Comparator | D5W | Unknown | 5 % | Intravenous |
| Comparator | Insulin | Protein / enzyme biologic | 80 iu | Intravenous |
| Comparator | Insulin | Protein / enzyme biologic | 100 iu | Intravenous |
| Comparator | Insulin | Protein / enzyme biologic | 160 iu | Intravenous |
| Comparator | KCL | Unknown | 40 meq | Intravenous |