drugset / Trial / NCT00466622
Uterine Artery Blood Flow in Pregnant Women With PCOS Treated With Metformin
Phase 3
Completed
48 enrolled
Norwegian University of Science and Technology
St. Olavs Hospital · collab
RandomizedParallel-groupQuadruple-blindPrevention
Summary
FlowMet study is a "sub-study" of the PregMet study (registered in 2005). The aim of the FlowMet study is to register the possible effect of metformin on the blood flow of the uterine artery in pregnant PCOS women. The participants will be examined with ultrasound Doppler in gestational week 10-13: 1. before and 3h after the first tablet intake of metformin/placebo 2. and 10-14 days after inclusion in the trial 3. blood flow in the umbilical artery and fetal cerebral artery in gestational week 24.
Timeline
- Start
- 2007-04
- Primary completion
- 2009-08
- Completion
- 2010-02
Publications
- Results Stridsklev S, Carlsen SM, Salvesen O, Clemens I, Vanky E. Midpregnancy Doppler ultrasound of the uterine artery in metformin- versus placebo-treated PCOS women: a randomized trial. J Clin Endocrinol Metab. 2014 Mar;99(3):972-7. doi: 10.1210/jc.2013-3227. Epub 2014 Jan 1.
- Stridsklev S, Salvesen O, Salvesen KA, Carlsen SM, Vanky E. Uterine Artery Doppler in Pregnancy: Women with PCOS Compared to Healthy Controls. Int J Endocrinol. 2018 Aug 16;2018:2604064. doi: 10.1155/2018/2604064. eCollection 2018.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Metformin | Small molecule | 1000 mg | Oral |