Opioid Rotation Versus Combination for Chronic Uncontrolled Cancer Pain

Phase 2 Completed 2006 enrolled Gachon University Gil Medical Center

RandomizedParallel-groupOpen-labelSupportive care

Summary

For cancer patients with inadequate pain relief, a switch to an alternative opioid is the preferred option for symptomatic improvement. However, multiple opioids are often simultaneously administered for anecdotal reasons. The present study isdesigned to assess the analgesic profiles of two different strategies in chronic cancer pain: the opioid rotation from oxycodone to transdermal fentanyl and the combination of oral oxycodone and transdermal fentanyl.

Timeline

Start: 2006-02
Primary completion: —
Completion: 2007-04

Publications

Kim HJ, Kim YS, Park SH. Opioid rotation versus combination for cancer patients with chronic uncontrolled pain: a randomized study. BMC Palliat Care. 2015 Sep 16;14:41. doi: 10.1186/s12904-015-0038-7.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Fentanyl	Other / unclassified	—	Other
Subject	Oxycodone	Other / unclassified	—	Oral

Indications

No indication recorded.