drugset / Trial / NCT00486954

Lapatinib in Combination With Weekly Paclitaxel in Patients With ErbB2 Amplified Advanced Gastric Cancer

NCT00486954

Phase 3 Completed 273 enrolled GlaxoSmithKline
RandomizedSingle-groupOpen-labelTreatment

Summary

EGF104578 is two-part study (Pilot part/Randomized part).Pilot part is designed to find the optimal (best) doses of lapatinib and paclitaxel when given together,Randomized part is designed to evaluate the overall survival in patients receiving lapatinib and paclitaxel compared to patients receiving only paclitaxel.

Timeline

Start
2007-07
Primary completion
2012-01
Completion
2012-10

Drugs

EvaluationDrugModalityDoseRoute
Subject Lapatinib Small molecule 1500 mg Oral
Background Paclitaxel Small molecule 80 mg/m2