drugset / Trial / NCT00492284

Reduced Fluence Visudyne-Anti-VEGF-Dexamethasone In Combination for AMD Lesions (RADICAL)

NCT00492284

Phase 2 Completed 162 enrolled QLT Inc.
RandomizedParallel-groupSingle-blindTreatment

Summary

The objective of this study is to determine if combination therapy (reduced-fluence Visudyne followed by Lucentis \[within 2 hours\] or either of two regimens of reduced-fluence Visudyne followed by Lucentis-Dexamethasone triple therapy \[within 2 hours\]) reduces retreatment rates compared with Lucentis monotherapy while maintaining similar vision outcomes and an acceptable safety profile.

Timeline

Start
2007-07
Primary completion
2009-05
Completion
2010-05

Drugs

EvaluationDrugModalityDoseRoute
Subject Dexamethasone Small molecule 0.5 mg Intravitreal
Subject Ranibizumab Monoclonal antibody 0.5 mg Intravitreal
Subject Verteporfin Other / unclassified