drugset / Trial / NCT00495183
Efficacy of Caffeine, With and Without Biperiden, as a Maintenance Treatment for Cocaine Dependence
RandomizedParallel-groupTriple-blindTreatment
Summary
The aim of this study is to assess the efficacy of caffeine compared to placebo as a maintenance treatment for cocaine dependence. Caffeine potentiation with biperiden will be also studied. Ninety patients with snorted/sniffed cocaine dependence will be randomized to receive caffeine (300 - 1200 mg t.i.d.) plus biperidene (8 mg b.i.d.) caffeine (300 - 1200 mg t.i.d.) with placebo or placebo during 10 days in an in-hospital setting.
Timeline
- Start
- 2009-01
- Primary completion
- 2010-07
- Completion
- 2010-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Biperiden | Small molecule | 2 mg | — |
| Subject | Biperiden | Small molecule | 4 mg | — |
| Subject | Caffeine | Small molecule | 15 mg/kg | — |
| Subject | Caffeine | Small molecule | 300 mg | — |
| Subject | Caffeine | Small molecule | 1200 mg | — |