drugset / Trial / NCT00495729
15-Day Repeated-Dose Study With SB-649868 And Its Interaction With CYP3A4 Isoenzyme In Healthy Male Subjects.
RandomizedSingle-groupTreatment
Summary
Subjects will be screened within 28 days, Simvastatin dose and single SB-649868 dose 10 and 7 days prior to repeat dosing respectively, 15 days SB-649868 repeat dosing with safety and cognition function tests.
Timeline
- Start
- 2007-04-18
- Primary completion
- 2007-08-04
- Completion
- 2007-08-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | SB-649868 | Small molecule | 5 mg | Oral |
| Subject | SB-649868 | Small molecule | 25 mg | Oral |
| Subject | Simvastatin | Small molecule | 10 mg | Oral |