drugset / Trial / NCT00504140
Recombinant Interferon Alpha and Etoposide in Relapsed Osteosarcoma
Non-randomizedSingle-groupOpen-labelTreatment
Summary
Primary Objectives: 1. To determine the efficacy of combining Interferon Alpha (IFN) with etoposide for the treatment of relapsed osteosarcoma. 2. To determine if IFN alters the plasma pharmacokinetics of etoposide. 3. To determine the toxicities of IFN and etoposide when administered together. 4. To determine IFN blood levels following combination therapy.
Timeline
- Start
- 1996-11
- Primary completion
- 2007-11
- Completion
- 2009-03
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Etoposide | Small molecule | 100 mg/m2 | Intravenous |
| Subject | interferon alfa-2b | Protein / enzyme biologic | 5e+06 unknown | Subcutaneous |