drugset / Trial / NCT00504946

Pharmacological Modulations of Allergen-Specific Immunotherapy

NCT00504946

Phase 3 Completed 85 enrolled Medical University of Lodz
RandomizedParallel-groupTriple-blindTreatment

Summary

There is mounting evidence that successful allergen immunotherapy (SIT) functions through the induction of different subset of Treg including Foxp3 positive cells, therefore additional strategies to enhance this property are highly attractive. Based on previous findings we assumed that combine allergen immunotherapy with non-specific treatments such as glucocorticosteroids and vitamin D3 as well as montelukast sodium treatment might enhanced allergen tolerance induction and improved clinical effectiveness of allergen-specific immunotherapy

Timeline

Start
2005-09
Primary completion
2007-03
Completion
2007-03

Drugs

EvaluationDrugModalityDoseRoute
Comparator Cholecalciferol Other / unclassified 1000 iu Oral
Comparator Montelukast Other / unclassified 5 mg Oral
Comparator Montelukast Other / unclassified 10 mg Oral
Comparator Prednisone Other / unclassified 20 mg Oral

Indications