drugset / Trial / NCT00507585
Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil, Leucovorin, and Avastin
NaSingle-groupOpen-labelTreatment
Summary
PRIMARY: * To determine the toxicity and tolerability of intra-arterial hepatic oxaliplatin every three weeks administered in combination with systemic intravenous Fluorouracil, Leucovorin and bevacizumab to patients with advanced solid tumors metastatic to the liver. SECONDARY: * To document in a descriptive fashion the antitumor efficacy of this combination regimen. * To evaluate the feasibility and accuracy of an alternate radiographic assessment tool and compare with available tumor markers and RECIST guidelines. * To estimate in a descriptive fashion the development of extrahepatic tumor recurrences.
Timeline
- Start
- 2006-06
- Primary completion
- 2010-01
- Completion
- 2010-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Oxaliplatin | Small molecule | 60 mg/m2 | Other |
| Background | Bevacizumab | Monoclonal antibody | 10 mg/m2 | Intravenous |
| Background | Leucovorin | Small molecule | 200 mg/m2 | Intravenous |
| Background | fluorouracil | Small molecule | 600 mg/m2 | Intravenous |