Effects on Ovarian Function of the Combined Oral Contraceptive NOMAC-E2 Compared to a COC Containing DRSP/EE (292003)(COMPLETED)(P05723)

Phase 3 Completed 48 enrolled Organon and Co

RandomizedParallel-groupOpen-labelPrevention

Summary

The primary purpose of this study is to evaluate the effects of the nomegestrol acetate-estradiol (NOMAC-E2) combined oral contraceptive (COC) on ovarian function.

Timeline

Start: 2006-10
Primary completion: 2008-01
Completion: 2008-01

Publications

Results Duijkers IJ, Klipping C, Grob P, Korver T. Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17 beta-oestradiol on ovarian function in comparison to a monophasic combined oral contraceptive containing drospirenone and ethinylestradiol. Eur J Contracept Reprod Health Care. 2010 Oct;15(5):314-25. doi: 10.3109/13625187.2010.504313.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Estradiol	Other / unclassified	1.5 mg	Oral
Subject	Nomegestrol Acetate	Small molecule	2.5 mg	Oral
Comparator	drospirenone	Unknown	3 mg	Oral
Comparator	ethinyl estradiol	Small molecule	30 ug	Oral

Indications

No indication recorded.