drugset / Trial / NCT00513864
Assessment of Opioid Analgesia in Sickle Cell
RandomizedCrossoverOpen-labelBasic science
Summary
To develop and validate a non-invasive, in vivo, phenotyping method for CYP2D6 using the non-injurious neuroselective electrical stimulation technique: pain perception threshold/pain tolerance threshold (PPT/PTT) in children and adolescents with sickle cell disease.
Timeline
- Start
- 2006-11
- Primary completion
- 2012-03
- Completion
- 2012-03
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Codeine | Small molecule | 2 mg/kg | Oral |
| Comparator | Dextromethorphan | Unknown | 0.3 mg/kg | Oral |
| Comparator | Morphine | Other / unclassified | 0.15 mg/kg | Intravenous |