Role of Volatile Anesthetics for Hepatic Protection

Completed University of Zurich

RandomizedParallel-groupOpen-labelPrevention

Summary

This study aims to evaluate the attenuation of ischemic-reperfusion injury in the liver after sevoflurane preconditioning. In the presence of sevoflurane, an attenuation of liver injury is hypothesized (diminished increase of liver enzymes, reduced production of inflammatory mediators).

Timeline

Start: 2006-03
Primary completion: 2007-12
Completion: 2007-12

Outcome

Met primary endpoint

paper Sevoflurane preconditioning significantly limited the postoperative increase of serum transaminase levels by 261 U/L (95% CI, 65 to 458; P = 0.01) PMID 19092335 ↗

Publications

Beck-Schimmer B, Breitenstein S, Urech S, De Conno E, Wittlinger M, Puhan M, Jochum W, Spahn DR, Graf R, Clavien PA. A randomized controlled trial on pharmacological preconditioning in liver surgery using a volatile anesthetic. Ann Surg. 2008 Dec;248(6):909-18. doi: 10.1097/SLA.0b013e31818f3dda.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Sevoflurane	Other / unclassified	—	—

Indications

No indication recorded.