A 52 Week Study to Evaluate the Effects of Losartan With or Without HCTZ on Plasma Glucose, Metabolic Parameters, Blood Pressure in Hypertensive Patients With Metabolic Syndrome (0954A-331)

Phase 3 Completed 1738 enrolled Organon and Co

Non-randomizedSingle-groupOpen-labelTreatment

Summary

To determine if a one year treatment Losartan with or without HCTZ at different dosages have an effect on metabolic parameters in patients with hypertension and the metabolic syndrome.

Timeline

Start: 2005-09-01
Primary completion: 2008-01-01
Completion: 2008-01-01

Publications

Results Racine N, Hamet P, Sampalis JS, Longo N, Bastien N. A 52-week prospective, cohort study of the effects of losartan with or without hydrochlorothiazide (HCTZ) in hypertensive patients with metabolic syndrome. J Hum Hypertens. 2010 Nov;24(11):739-48. doi: 10.1038/jhh.2010.3. Epub 2010 Feb 11.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Hydrochlorothiazide	Unknown	12.5 mg	—
Subject	Hydrochlorothiazide	Unknown	25 mg	—
Subject	Losartan	Other / unclassified	50 mg	—
Subject	Losartan	Other / unclassified	100 mg	—

A 52 Week Study to Evaluate the Effects of Losartan With or Without HCTZ on Plasma Glucose, Metabolic Parameters, Blood Pressure in Hypertensive Patients With Metabolic Syndrome (0954A-331)

Summary

Timeline

Publications

Drugs

Indications