A Study to Evaluate the Effectiveness of Cosopt® as First Line Therapy (MK-0507A-153)

Phase 3 Completed 170 enrolled Merck Sharp & Dohme LLC

Non-randomizedSingle-groupOpen-labelTreatment

Summary

Evaluate the effectiveness of dorzolamide-timolol (Cosopt®) as first line therapy in reducing intraocular pressure in patients with untreated Open angle glaucoma (OAG) or Ocular hypertension (OH).

Timeline

Start: 2006-05-31
Primary completion: 2007-08-23
Completion: 2007-08-23

Publications

Results Crichton AC, Harasymowycz P, Hutnik CM, Behki R, Boucher S, Ibrahim F, Rifkind AW, Solomon L, Liao C, Bastien NR, Sampalis JS. Effectiveness of dorzolamide-timolol (COSOPT) in patients who were treatment naive for open-angle glaucoma or ocular hypertension: the COSOPT first-line study. J Ocul Pharmacol Ther. 2010 Oct;26(5):503-11. doi: 10.1089/jop.2010.0032.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dorzolamide	Small molecule	2 %	—
Subject	Latanoprost	Small molecule	—	—
Subject	Timolol	Other / unclassified	0.5 %	—

A Study to Evaluate the Effectiveness of Cosopt® as First Line Therapy (MK-0507A-153)

Summary

Timeline

Publications

Drugs

Indications