BP-EASE -Effectiveness of Losartan 50 mg/Hydrochlorothiazide (HCTZ) 12.5 mg Versus Valsartan 80 mg/HCTZ 12.5 mg Titrated as Needed in Patients With Essential Hypertension Not Controlled on Monotherapy (0954A-333)

Summary

To evaluate the blood pressure efficacy between losartan and valsartan at equivalent dosage during a 3 months treatment.

Timeline

Start

2007-05-01

Primary completion

2009-04-01

Completion

2009-05-01

Outcome

Missed primary endpoint

registry analysis (unspecified test); Losartan 50 mg/HCTZ 12.5 mg vs Valsartan 80 mg/HCTZ 12.5 mg; p = 0.395; ANOVA NCT00546754 ↗

registry analysis (unspecified test); Losartan 50 mg/HCTZ 12.5 mg vs Valsartan 80 mg/HCTZ 12.5 mg; p = 0.935; ANOVA NCT00546754 ↗

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Losartan	Other / unclassified	50 mg	—
Subject	Losartan	Other / unclassified	100 mg	—
Comparator	Valsartan	Unknown	80 mg	—
Comparator	Valsartan	Unknown	160 mg	—
Comparator	Hydrochlorothiazide	Unknown	12.5 mg	—
Comparator	Hydrochlorothiazide	Unknown	25 mg	—

Indications