Arterial Pressure Based Cardiac Output for Goal-Directed Therapy in Abdominal Surgery

Phase 4 Completed 60 enrolled Klinikum Ludwigshafen

RandomizedParallel-groupSingle-blindTreatment

Summary

The purpose of this study is to determine whether the early identification and more precise intervention of goal-directed intraoperative plasma volume expansion and catecholamine therapy using arterial pressure based cardiac output (APCO) measurement in addition to normal vital signs will improve postoperative organ function, in particular renal function, in patients undergoing major abdominal surgery.

Timeline

Start: 2007-10
Primary completion: 2009-01
Completion: 2009-04

Publications

Mayer J, Boldt J, Mengistu AM, Rohm KD, Suttner S. Goal-directed intraoperative therapy based on autocalibrated arterial pressure waveform analysis reduces hospital stay in high-risk surgical patients: a randomized, controlled trial. Crit Care. 2010;14(1):R18. doi: 10.1186/cc8875. Epub 2010 Feb 15.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Dobutamine	Small molecule	—	—
Comparator	Norepinephrine	Other / unclassified	—	—
Comparator	Ringer's Lactate	Other / unclassified	—	—
Comparator	hydroxyethyl starch	Other / unclassified	—	—

Indications

No indication recorded.