A Study to Test a New Decongestant in Patients With Allergic Rhinitis Following a Nasal Allergen Challenge

Summary

An H3 receptor antagonist should reduce the congestion associated with allergic rhinitis. A nasal allergen challenge will be given to patients to induce rhinitis symptoms and acoustic rhinometry will be used to measure the congestion.

Timeline

Start

2007-12

Primary completion

2008-08

Completion

2008-08

Outcome

Missed primary endpoint

registry analysis (superiority or other test); PF-03654746 10 mg vs Placebo; p = 0.302; ANOVA; NCT00562120 ↗

registry analysis (superiority or other test); PF-03654746 1 mg vs Placebo; p = 0.229; ANOVA; NCT00562120 ↗

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Allegra-D	Unknown	—	Oral
Comparator	Fexofenadine	Unknown	—	Oral
Subject	PF-03654746	Small molecule	—	Oral

Indications