Intravenous Phenoxybenzamine Use in Pediatric Patients Undergoing Open-Heart Surgery

Phase 2 Completed 785 enrolled University of Arkansas Arkansas Children's Hospital Research Institute · collab

NaSingle-groupOpen-labelTreatment

Summary

Cardiopulmonary bypass is done with a machine that does the work of the heart and lungs during open-heart surgery. This study is to determine if intravenous (i.v.) phenoxybenzamine is safe. This drug lowers the blood pressure, making it easier for the cardiopulmonary bypass machine to deliver blood and oxygen to all of the organs and tissues.

Timeline

Start: 2001-02
Primary completion: 2010-08
Completion: 2010-08

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Phenoxybenzamine	Small molecule	0.125 mg/kg	Intravenous
Subject	Phenoxybenzamine	Small molecule	1 mg/kg	Intravenous

Indications

No indication recorded.