drugset / Trial / NCT00579878
Triple III Comparison of Leflunomide Alone Versus Two DMARD Combinations in the Treatment of Rheumatoid Arthritis
RandomizedParallel-groupQuadruple-blindTreatment
Summary
The study has been designed as a 48-week, double-blind, randomized, controlled study comparing the use of leflunomide alone to combinations of leflunomide-sulfasalazine-HCQ, and methotrexate-sulfasalazine-HCQ.
Timeline
- Start
- 2001-03-27
- Primary completion
- 2010-03-11
- Completion
- 2010-03-11
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Hydroxychloroquine | Small molecule | 400 mg | — |
| Comparator | Leflunomide | Small molecule | 20 mg | — |
| Comparator | Methotrexate | Small molecule | 20 mg | — |
| Comparator | Sulfasalazine | Small molecule | 2000 mg | — |