drugset / Trial / NCT00581477
Treatment of Orthostatic Hypotension
Phase 2/3
Terminated
8 enrolled
Vanderbilt University
National Heart, Lung, and Blood Institute (NHLBI) · collab
NaSingle-groupOpen-labelTreatment
Summary
The purpose of this study is to try different medications in patients with low blood pressure and other problems with their involuntary (autonomic) nervous system. The pharmacological trials in this study will perhaps lead to more effective treatment. The protocol includes single dose trials, dose-selection trials, 5-day trials and chronic (approximately 2 months) trials, although only dose-selection trials were consistently performed and have results presented.
Timeline
- Start
- 2004-01
- Primary completion
- 2020-12
- Completion
- 2020-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Droxidopa | Small molecule | 25 mg | Oral |
| Subject | Droxidopa | Small molecule | 50 mg | Oral |
| Subject | Droxidopa | Small molecule | 100 mg | Oral |
| Subject | Droxidopa | Small molecule | 200 mg | Oral |
| Subject | Droxidopa | Small molecule | 250 mg | Oral |
| Subject | Droxidopa | Small molecule | 300 mg | Oral |